NODding off in acute kidney injury with progranulin?

Raghu K. Tadagavadi; W. Brian Reeves

doi:10.1038/ki.2015.14

NODding off in acute kidney injury with progranulin?

Raghu K. Tadagavadi, W. Brian Reeves

Research output: Contribution to journal › Comment/debate › peer-review

4 Scopus citations

Abstract

Zhou et al. identify progranulin (PGRN) as a protective mediator that limits inflammation in murine models of acute kidney injury (AKI) and reduces its severity. Deficiency of PGRN was associated with increased inflammation and increased injury in ischemic and nephrotoxic models of AKI. Exogenous PGRN reduced AKI even when administered after AKI was established. Interference in NOD2 pathways is suggested as a possible mechanism for protection. PGRN-based therapeutics might have application in the treatment or prevention of AKI.

Original language	English (US)
Pages (from-to)	873-875
Number of pages	3
Journal	Kidney international
Volume	87
Issue number	5
DOIs	https://doi.org/10.1038/ki.2015.14
State	Published - May 11 2015
Externally published	Yes

ASJC Scopus subject areas

Nephrology

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10.1038/ki.2015.14

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@article{c51b2a9012fe4657ba53071c85762fb4,

title = "NODding off in acute kidney injury with progranulin?",

abstract = "Zhou et al. identify progranulin (PGRN) as a protective mediator that limits inflammation in murine models of acute kidney injury (AKI) and reduces its severity. Deficiency of PGRN was associated with increased inflammation and increased injury in ischemic and nephrotoxic models of AKI. Exogenous PGRN reduced AKI even when administered after AKI was established. Interference in NOD2 pathways is suggested as a possible mechanism for protection. PGRN-based therapeutics might have application in the treatment or prevention of AKI.",

author = "Tadagavadi, {Raghu K.} and Reeves, {W. Brian}",

note = "Funding Information: R.K.T. and W.B.R. are supported by National Institutes of Health grant DK081876.",

year = "2015",

month = may,

day = "11",

doi = "10.1038/ki.2015.14",

language = "English (US)",

volume = "87",

pages = "873--875",

journal = "Kidney International",

issn = "0085-2538",