Nocturnal serum melatonin in major depressive disorder before and after desmethylimipramine treatment

R. P. Brown, S. Caroff, J. H. Kocsis, J. Amsterdam, A. Winokur, P. Stokes, A. Frazer

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The major finding from the studies of untreated depressives was reduced nocturnal concentrations of serum melatonin when patients with major depressive disorder, melancholic subtype, were compared to major depressives without melancholia or healthy controls. In our study, an association between symptoms of melancholia and DST nonsuppression was noted. The results obtained in the subset of depressed patients treated with DMI were different from those previously found in rats treated with he same antidepressant. One plausible explanation for the difference between results of the rat and human studies might be the lower concentration of DMI in plasma in the current study (70 ± 9 ng/ml) compared to rats (347 ± 75 ng/ml).

Original languageEnglish (US)
Pages (from-to)579-581
Number of pages3
JournalPsychopharmacology bulletin
Volume21
Issue number3
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

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