Nocturnal decreases in nitric oxide and cyclic GMP contents in the chick brain and their prevention by light

Juan M. Guerrero; Marta I. Pablos; Genaro G. Ortiz; Maria T. Agapito; Russel J. Reiter

doi:10.1016/0197-0186(95)00162-X

Nocturnal decreases in nitric oxide and cyclic GMP contents in the chick brain and their prevention by light

Juan M. Guerrero, Marta I. Pablos, Genaro G. Ortiz, Maria T. Agapito, Russel J. Reiter

Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

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Abstract

The diurnal variations in the contents of nitric oxide (NO) and cyclic GMP were studied in the chick brain. NO and cyclic GMP contents in the chick brain were lower at night than during the day and were inversely correlated with high night-time tissue melatonin levels. Furthermore, when animals were kept in light at night, tissue melatonin levels remained at low diurnal values, whereas NO and cyclic GMP contents remained high. Since we have previously shown that physiological concentrations of melatonin inhibit nitric oxide synthase (NOS) activity in different brain areas, the nocturnal decrease in brain NO and cyclic GMP contents may be, in part, a consequence of the nocturnal inhibitory effect of melatonin on NOS activity.

Original language	English (US)
Pages (from-to)	417-421
Number of pages	5
Journal	Neurochemistry International
Volume	29
Issue number	4
DOIs	https://doi.org/10.1016/0197-0186(95)00162-X
State	Published - Oct 1996

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Cell Biology

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title = "Nocturnal decreases in nitric oxide and cyclic GMP contents in the chick brain and their prevention by light",

abstract = "The diurnal variations in the contents of nitric oxide (NO) and cyclic GMP were studied in the chick brain. NO and cyclic GMP contents in the chick brain were lower at night than during the day and were inversely correlated with high night-time tissue melatonin levels. Furthermore, when animals were kept in light at night, tissue melatonin levels remained at low diurnal values, whereas NO and cyclic GMP contents remained high. Since we have previously shown that physiological concentrations of melatonin inhibit nitric oxide synthase (NOS) activity in different brain areas, the nocturnal decrease in brain NO and cyclic GMP contents may be, in part, a consequence of the nocturnal inhibitory effect of melatonin on NOS activity.",

author = "Guerrero, {Juan M.} and Pablos, {Marta I.} and Ortiz, {Genaro G.} and Agapito, {Maria T.} and Reiter, {Russel J.}",

note = "Funding Information: Work by the authors was supported by grants from NSF and NIH, a Movilidad del Profesorado fellowship from the Spanish Government (J. M. Guerrero), and a NATO fellowship (M. I. Pablos), fellowship from the Instituto Mexicano del Seguro Social, and Movilidad del Profesorado fellowship from the University of Valladolid (M. T. Agapito). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "1996",

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doi = "10.1016/0197-0186(95)00162-X",

language = "English (US)",

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T1 - Nocturnal decreases in nitric oxide and cyclic GMP contents in the chick brain and their prevention by light

AU - Guerrero, Juan M.

AU - Pablos, Marta I.

AU - Ortiz, Genaro G.

AU - Agapito, Maria T.

AU - Reiter, Russel J.

N1 - Funding Information: Work by the authors was supported by grants from NSF and NIH, a Movilidad del Profesorado fellowship from the Spanish Government (J. M. Guerrero), and a NATO fellowship (M. I. Pablos), fellowship from the Instituto Mexicano del Seguro Social, and Movilidad del Profesorado fellowship from the University of Valladolid (M. T. Agapito). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 1996/10

Y1 - 1996/10

N2 - The diurnal variations in the contents of nitric oxide (NO) and cyclic GMP were studied in the chick brain. NO and cyclic GMP contents in the chick brain were lower at night than during the day and were inversely correlated with high night-time tissue melatonin levels. Furthermore, when animals were kept in light at night, tissue melatonin levels remained at low diurnal values, whereas NO and cyclic GMP contents remained high. Since we have previously shown that physiological concentrations of melatonin inhibit nitric oxide synthase (NOS) activity in different brain areas, the nocturnal decrease in brain NO and cyclic GMP contents may be, in part, a consequence of the nocturnal inhibitory effect of melatonin on NOS activity.

AB - The diurnal variations in the contents of nitric oxide (NO) and cyclic GMP were studied in the chick brain. NO and cyclic GMP contents in the chick brain were lower at night than during the day and were inversely correlated with high night-time tissue melatonin levels. Furthermore, when animals were kept in light at night, tissue melatonin levels remained at low diurnal values, whereas NO and cyclic GMP contents remained high. Since we have previously shown that physiological concentrations of melatonin inhibit nitric oxide synthase (NOS) activity in different brain areas, the nocturnal decrease in brain NO and cyclic GMP contents may be, in part, a consequence of the nocturnal inhibitory effect of melatonin on NOS activity.

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JF - Neurochemistry International

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Nocturnal decreases in nitric oxide and cyclic GMP contents in the chick brain and their prevention by light

Abstract

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