No major effect of the insulin-like growth factor I gene on bone mineral density in premenopausal Chinese women

De Ke Jiang, Hui Shen, Miao Xin Li, Cheng Jiang, Na Yang, Jie Zhu, Yong Wu, Yue Juan Qin, Qi Zhou, Hong Wen Deng

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Osteoporosis is a major public health problem, mainly characterized by low bone mineral density (BMD). BMD is a complex trait that is determined by multiple genes. Insulin-like growth factor I (IGF-I) is an important growth factor of bone and thus IGF-I gene has been considered as an attractive candidate gene for osteoporosis. A few studies on the relationship between variants of the IGF-I gene and BMD variation, via traditional association and/or linkage methods, have yielded conflicting results. In this study, we simultaneously tested association and/or linkage of a cytosine-adenine (CA) repeat polymorphism at 1 kb upstream of the transcription initiation site of the IGF-I gene with BMD variation in a large cohort of premenopausal Chinese women. A total of 1263 subjects from 402 Chinese nuclear families were examined. Each family consists of both parents and at least one daughter aged between 20 and 45 years. BMDs (g/cm2) at the lumbar spine and hip were measured using dual-energy X-ray absorptiometry (DXA). Applying the QTDT (quantitative transmission disequilibrium tests) progam, we did not find significant evidence of association or linkage between the CA repeat polymorphism of the IGF-I gene and BMD variation at any skeletal site. Our data do not support the IGF-I gene having major effect on BMD variation in premenopausal Chinese women.

Original languageEnglish (US)
Pages (from-to)694-699
Number of pages6
JournalBone
Volume36
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

Keywords

  • Association
  • Bone mineral density
  • IGF-I gene
  • Linkage
  • Osteoporosis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Histology
  • Physiology

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