No effect of melatonin on oxidative stress after laparoscopic cholecystectomy: A randomized placebo-controlled trial

B. Kücükakin, M. Klein, J. Lykkesfeldt, R. J. Reiter, J. Rosenberg, I. GÖgenur

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Background: Melatonin, an endogenous circadian regulator, also has antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the antioxidative effect of melatonin in patients undergoing laparoscopic cholecystectomy. Methods: Patients were randomized to receive 10 mg melatonin or placebo during surgery. Blood samples for analysis of malondialdehyde (MDA), ascorbic acid (AA), total ascorbic acid (TAA) dehydroascorbic acid (DHA) and C-reactive protein (CRP) were collected pre-operatively and at 5 min, 6 h and 24 h after operation. Results: Twenty patients received melatonin and 21 patients received placebo during surgery. No significant differences were observed between the groups in the oxidative stress variables MDA, TAA, AA and DHA or in the inflammatory variable CRP (repeated-measures ANOVA, P>0.05 for all variables). Conclusions: Administration of 10 mg melatonin did not reduce variables of oxidative stress in patients undergoing elective laparoscopic cholecystectomy.

Original languageEnglish (US)
Pages (from-to)1121-1127
Number of pages7
JournalActa Anaesthesiologica Scandinavica
Volume54
Issue number9
DOIs
StatePublished - Oct 1 2010

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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