No difference in day-night serum melatonin concentration after pineal grafting into the third cerebral ventricle of pinealectomized rats

W. Wu, D. E. Scott, Russel J Reiter

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Serum melatonin concentration and its day-night difference in pinealectomized, stereotaxically grafted rats with pineal transplants was examined. The nighttime serum melatonin concentration increased significantly only in pinealectomized rats that received two pineal transplants. In neither pinealectomized rats receiving two pineal glands and one cotransplant of superior cervical sympathetic ganglion nor pinealectomized-ganglionectomized rats receiving two pineal transplants was there a demonstrable increase in serum melatonin concentration. Although some pineal transplanted hosts demonstrated increases in serum melatonin concentration, there was no day- night variation in serum melatonin concentration. This may be due to a number of mitigating factors. Pineal grafts may not receive the appropriate functional reinnervation from the host brain due to the location of the transplantation in the cerebral ventricle or due to lack of sufficient time for the growth of invading host neurites.

Original languageEnglish (US)
Pages (from-to)70-74
Number of pages5
JournalJournal of Pineal Research
Volume11
Issue number2
StatePublished - 1991

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Cerebral Ventricles
Third Ventricle
Melatonin
Transplants
Serum
Superior Cervical Ganglion
Sympathetic Ganglia
Pineal Gland
Neurites
Transplantation
Brain
Growth

ASJC Scopus subject areas

  • Endocrinology

Cite this

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abstract = "Serum melatonin concentration and its day-night difference in pinealectomized, stereotaxically grafted rats with pineal transplants was examined. The nighttime serum melatonin concentration increased significantly only in pinealectomized rats that received two pineal transplants. In neither pinealectomized rats receiving two pineal glands and one cotransplant of superior cervical sympathetic ganglion nor pinealectomized-ganglionectomized rats receiving two pineal transplants was there a demonstrable increase in serum melatonin concentration. Although some pineal transplanted hosts demonstrated increases in serum melatonin concentration, there was no day- night variation in serum melatonin concentration. This may be due to a number of mitigating factors. Pineal grafts may not receive the appropriate functional reinnervation from the host brain due to the location of the transplantation in the cerebral ventricle or due to lack of sufficient time for the growth of invading host neurites.",
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AU - Scott, D. E.

AU - Reiter, Russel J

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N2 - Serum melatonin concentration and its day-night difference in pinealectomized, stereotaxically grafted rats with pineal transplants was examined. The nighttime serum melatonin concentration increased significantly only in pinealectomized rats that received two pineal transplants. In neither pinealectomized rats receiving two pineal glands and one cotransplant of superior cervical sympathetic ganglion nor pinealectomized-ganglionectomized rats receiving two pineal transplants was there a demonstrable increase in serum melatonin concentration. Although some pineal transplanted hosts demonstrated increases in serum melatonin concentration, there was no day- night variation in serum melatonin concentration. This may be due to a number of mitigating factors. Pineal grafts may not receive the appropriate functional reinnervation from the host brain due to the location of the transplantation in the cerebral ventricle or due to lack of sufficient time for the growth of invading host neurites.

AB - Serum melatonin concentration and its day-night difference in pinealectomized, stereotaxically grafted rats with pineal transplants was examined. The nighttime serum melatonin concentration increased significantly only in pinealectomized rats that received two pineal transplants. In neither pinealectomized rats receiving two pineal glands and one cotransplant of superior cervical sympathetic ganglion nor pinealectomized-ganglionectomized rats receiving two pineal transplants was there a demonstrable increase in serum melatonin concentration. Although some pineal transplanted hosts demonstrated increases in serum melatonin concentration, there was no day- night variation in serum melatonin concentration. This may be due to a number of mitigating factors. Pineal grafts may not receive the appropriate functional reinnervation from the host brain due to the location of the transplantation in the cerebral ventricle or due to lack of sufficient time for the growth of invading host neurites.

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