No Detrimental Effect of a Positive Family History on Long-Term Outcomes Following Radical Prostatectomy

Johannes M S Brath, Sonja Grill, Donna P Ankerst, Ian M. Thompson, Juergen E. Gschwend, Kathleen Herkommer

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Purpose Overall 1 in 5 patients with prostate cancer has a positive family history. In this report we evaluated the association between family history and long-term outcomes following radical prostatectomy. Materials and Methods Patients treated with radical prostatectomy were identified from a German registry, and separated into positive first-degree family history vs negative family history (strictly negative, requiring at least 1 male first-degree relative older than 60 years and no prostate cancer in the family). Kaplan-Meier curves and Cox proportional hazards models were used for association analyses with biochemical recurrence-free and prostate cancer specific survival. Results Median followup for 7,690 men included in the study was 8.4 years. Of the 754 younger patients less than 55 years old 50.9% (384) had a family history compared to 40.4% of the older patients (2,803; p 0.05). Prostate specific antigen, pathological stage, node stage and Gleason score were the only significant predictors for biochemical recurrence-free survival, while pathological stage, node stage (all p

Original languageEnglish (US)
Pages (from-to)343-348
Number of pages6
JournalJournal of Urology
Volume195
Issue number2
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

Keywords

  • age factors
  • family
  • prostatectomy
  • prostatic neoplasms
  • survival rate

ASJC Scopus subject areas

  • Urology

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