No association between genetic polymorphisms of the NDUFS7 gene and schizophrenia in Han Chinese

Liang Ma, Wen Zhang, Jinsong Tang, Liwen Tan, Yong Gang Yao, Xiaogang Chen

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Accumulating evidence suggests that mitochondrial dysfunction contributes toward the pathogenesis of psychiatric diseases. NADH dehydrogenase Fe-S protein 7 (NDUFS7), a subunit of respiratory chain complex I, has been reported recently to be associated with bipolar disorder. To test whether this gene can confer a wide variety of psychiatric disorders, we carried out a case-control association analysis of three tagging single-nucleotide polymorphisms (rs2074896, rs2074897, and rs2074898) in the NDUFS7 gene by sequencing 330 Han Chinese patients with schizophrenia and 330 well-matched healthy controls. We found no significant difference in the frequency distributions of alleles, genotypes, and haplotypes between the cases and the controls, indicating no active role of this gene in schizophrenia.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalPsychiatric Genetics
Volume23
Issue number1
DOIs
StatePublished - Feb 2013
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

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