Nitroalkane oxidase: Structure and mechanism

Paul F. Fitzpatrick

doi:10.1016/j.abb.2017.05.012

Nitroalkane oxidase: Structure and mechanism

Paul F. Fitzpatrick

Biochemistry & Structural Biology

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

The flavoprotein nitroalkane oxidase catalyzes the oxidation of neutral nitroalkanes to the corresponding aldehydes or ketones, releasing nitrite and transferring electrons to O₂ to form H₂O₂. A combination of solution and structural analyses have provided a detailed understanding of the mechanism of this enzyme.

Original language	English (US)
Pages (from-to)	41-46
Number of pages	6
Journal	Archives of Biochemistry and Biophysics
Volume	632
DOIs	https://doi.org/10.1016/j.abb.2017.05.012
State	Published - Oct 15 2017

Keywords

Flavoprotein
Mechanism
Nitroalkane oxidase
Nitronate monooxygenase
Structure

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology

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title = "Nitroalkane oxidase: Structure and mechanism",

abstract = "The flavoprotein nitroalkane oxidase catalyzes the oxidation of neutral nitroalkanes to the corresponding aldehydes or ketones, releasing nitrite and transferring electrons to O2 to form H2O2. A combination of solution and structural analyses have provided a detailed understanding of the mechanism of this enzyme.",

keywords = "Flavoprotein, Mechanism, Nitroalkane oxidase, Nitronate monooxygenase, Structure",

author = "Fitzpatrick, {Paul F.}",

note = "Funding Information: The work from the author's laboratory described here was supported in part by NIH grant GM058698 . ",

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T2 - Structure and mechanism

AU - Fitzpatrick, Paul F.

N1 - Funding Information: The work from the author's laboratory described here was supported in part by NIH grant GM058698 .

PY - 2017/10/15

Y1 - 2017/10/15

N2 - The flavoprotein nitroalkane oxidase catalyzes the oxidation of neutral nitroalkanes to the corresponding aldehydes or ketones, releasing nitrite and transferring electrons to O2 to form H2O2. A combination of solution and structural analyses have provided a detailed understanding of the mechanism of this enzyme.

AB - The flavoprotein nitroalkane oxidase catalyzes the oxidation of neutral nitroalkanes to the corresponding aldehydes or ketones, releasing nitrite and transferring electrons to O2 to form H2O2. A combination of solution and structural analyses have provided a detailed understanding of the mechanism of this enzyme.

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KW - Nitroalkane oxidase

KW - Nitronate monooxygenase

KW - Structure

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DO - 10.1016/j.abb.2017.05.012

M3 - Review article

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