Nitric oxide modulates Ca2+ channel currents in rat sympathetic neurons

Chu Chen, Geoffrey G. Schofield

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


The effects of nitric oxide on the Ca2+ channel currents of adult rat superior cervical ganglion neurons were investigated using the whole-cell patch-clamp technique. Nitric oxide-containing compounds sodium nitroprusside and S-nitroso-N-acetyl-penicillamine increased the amplitude of Ca2+ currents by intracellular application. In addition, both sodium nitroprusside and S-nitroso-N-acetylpenicillamine reduced norepinephrine-induced inhibition of Ca2+ currents. The results suggest that nitric oxide might be involved in the modulation of Ca2+-dependent neurotransmission in sympathetic neurons.

Original languageEnglish (US)
Pages (from-to)83-86
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number1
StatePublished - Oct 12 1993
Externally publishedYes


  • Ca channels
  • Nitric oxide (NO)
  • Norepinephrine
  • Patch-clamp
  • Sympathetic ganglion
  • Voltage-clamp

ASJC Scopus subject areas

  • Pharmacology


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