Nitric oxide inhibits enterocyte mitochondrial phospholipase D

M. Madesh, K. A. Balasubramanian

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Mitochondrial damage is one of the prominent features of cell death in oxidative stress and related pathological conditions. Alteration in membrane lipid composition may be responsible for the mitochondrial damage. In this study, we have shown that intestinal mitochondria contain an active phospholipase D (PLD) which is activated by oxidants, Ca2+ or polyamines and this results in degradation of phosphatidylethanolamine (PE) and formation of phosphatidic acid (PA). This PLD activity is inhibited by nitric oxide (NO) which prevents the lipid alteration in mitochondria when exposed to these agents. This can be reversed by the NO scavenger, haemoglobin. This suggests that alteration of mitochondrial membrane lipid composition by activation of PLD in certain pathological condition such as oxidative stress may be prevented by the simultaneous presence of nitric oxide.

Original languageEnglish (US)
Pages (from-to)269-272
Number of pages4
JournalFEBS Letters
Volume413
Issue number2
DOIs
StatePublished - Aug 18 1997
Externally publishedYes

Keywords

  • Enterocyte mitochondria
  • Nitric oxide
  • Phosphatidic acid
  • Phosphatidylethanolamine
  • Phospholipase D

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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