NIH3T3 transforming gene not a general feature of atherosclerotic plaque DNA. (atherosclerosis/oncogene/NIH3T3 transfection assay)

P. Renee Yew, Tripathi B. Rajavashisth, James Forrester, Peter Barath, Aldons J. Lusis

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A recent study indicated that the DNA isolated from human coronary atherosclerotic lesions is capable of transforming NIH3T3 cells in culture. Using DNA isolated from rabbit aortic and human carotid atherosclerotic lesions, we failed to observed such transforming activity. Thus, NIH3T3 transforming activity does not appear to be a general feature of atherosclerotic lesions.

Original languageEnglish (US)
Pages (from-to)1067-1071
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume165
Issue number3
DOIs
StatePublished - Dec 30 1989
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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