Nigerian HIV type 2 subtype A and B from heterotypic HIV type 1 and HIV type 2 or monotypic HIV type 2 infections

Clement Zeh; Danuta Pieniazek; Simon M. Agwale; Kenneth E. Robbins; Lillian Odama; N. Sani-Gwarzo; Michael S. Gboun; Uford S. Inyang; Thomas M. Folks; Charles Wambebe; Marcia L. Kalish

doi:10.1089/aid.2005.21.17

Nigerian HIV type 2 subtype A and B from heterotypic HIV type 1 and HIV type 2 or monotypic HIV type 2 infections

Clement Zeh, Danuta Pieniazek, Simon M. Agwale, Kenneth E. Robbins, Lillian Odama, N. Sani-Gwarzo, Michael S. Gboun, Uford S. Inyang, Thomas M. Folks, Charles Wambebe, Marcia L. Kalish

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The presence of HIV-2 in Nigeria has been confirmed serologically, but not genetically. To determine the frequency of HIV-2 infections and the dynamics between HIV-1 and HIV-2 in 35 of 36 Nigerian states, 420 blood samples were collected in 1999. Antibodies to HIV-1 and HIV-2 were detected by EIA and seroreactivity was confirmed with the INNO-LIA HIV Line Assay. The frequency of HIV-2 was 4.3% (18 of 420), with 3.8% (16 of 420) HIV-1 and HIV-2 (HIV-1/2) heterotypic and 0.5% (2 of 420) HIV-2 homotypic infections. The presence of HIV-2 subtype B in the two monotypic HIV-2 infections and subtype A in 11 (68.8%) of 16 HIV-1/2 dually seropositive samples was established by sequencing and phylogenetic analysis. HIV-2 subtype B viruses were not found in any of the HIV-1/2 dual infections, and HIV-2 subtype A strains were not identified in either of the two monotypic HIV-2 infections. Since our sample size was small and represented only convenience samples, larger randomized studies will be needed to better understand the dynamics of infection between HIV-1 and different HIV-2 subtypes and to determine whether significant biological differences exist among the HIV-2 subtypes.

Original language	English (US)
Pages (from-to)	17-27
Number of pages	11
Journal	AIDS Research and Human Retroviruses
Volume	21
Issue number	1
DOIs	https://doi.org/10.1089/aid.2005.21.17
State	Published - Jan 1 2005

ASJC Scopus subject areas

Immunology
Virology
Infectious Diseases

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Nigerian HIV type 2 subtype A and B from heterotypic HIV type 1 and HIV type 2 or monotypic HIV type 2 infections. / Zeh, Clement; Pieniazek, Danuta; Agwale, Simon M.; Robbins, Kenneth E.; Odama, Lillian; Sani-Gwarzo, N.; Gboun, Michael S.; Inyang, Uford S.; Folks, Thomas M.; Wambebe, Charles; Kalish, Marcia L.

In: AIDS Research and Human Retroviruses, Vol. 21, No. 1, 01.01.2005, p. 17-27.

Research output: Contribution to journal › Article › peer-review

Zeh, Clement ; Pieniazek, Danuta ; Agwale, Simon M. ; Robbins, Kenneth E. ; Odama, Lillian ; Sani-Gwarzo, N. ; Gboun, Michael S. ; Inyang, Uford S. ; Folks, Thomas M. ; Wambebe, Charles ; Kalish, Marcia L. / Nigerian HIV type 2 subtype A and B from heterotypic HIV type 1 and HIV type 2 or monotypic HIV type 2 infections. In: AIDS Research and Human Retroviruses. 2005 ; Vol. 21, No. 1. pp. 17-27.

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abstract = "The presence of HIV-2 in Nigeria has been confirmed serologically, but not genetically. To determine the frequency of HIV-2 infections and the dynamics between HIV-1 and HIV-2 in 35 of 36 Nigerian states, 420 blood samples were collected in 1999. Antibodies to HIV-1 and HIV-2 were detected by EIA and seroreactivity was confirmed with the INNO-LIA HIV Line Assay. The frequency of HIV-2 was 4.3% (18 of 420), with 3.8% (16 of 420) HIV-1 and HIV-2 (HIV-1/2) heterotypic and 0.5% (2 of 420) HIV-2 homotypic infections. The presence of HIV-2 subtype B in the two monotypic HIV-2 infections and subtype A in 11 (68.8%) of 16 HIV-1/2 dually seropositive samples was established by sequencing and phylogenetic analysis. HIV-2 subtype B viruses were not found in any of the HIV-1/2 dual infections, and HIV-2 subtype A strains were not identified in either of the two monotypic HIV-2 infections. Since our sample size was small and represented only convenience samples, larger randomized studies will be needed to better understand the dynamics of infection between HIV-1 and different HIV-2 subtypes and to determine whether significant biological differences exist among the HIV-2 subtypes.",

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AB - The presence of HIV-2 in Nigeria has been confirmed serologically, but not genetically. To determine the frequency of HIV-2 infections and the dynamics between HIV-1 and HIV-2 in 35 of 36 Nigerian states, 420 blood samples were collected in 1999. Antibodies to HIV-1 and HIV-2 were detected by EIA and seroreactivity was confirmed with the INNO-LIA HIV Line Assay. The frequency of HIV-2 was 4.3% (18 of 420), with 3.8% (16 of 420) HIV-1 and HIV-2 (HIV-1/2) heterotypic and 0.5% (2 of 420) HIV-2 homotypic infections. The presence of HIV-2 subtype B in the two monotypic HIV-2 infections and subtype A in 11 (68.8%) of 16 HIV-1/2 dually seropositive samples was established by sequencing and phylogenetic analysis. HIV-2 subtype B viruses were not found in any of the HIV-1/2 dual infections, and HIV-2 subtype A strains were not identified in either of the two monotypic HIV-2 infections. Since our sample size was small and represented only convenience samples, larger randomized studies will be needed to better understand the dynamics of infection between HIV-1 and different HIV-2 subtypes and to determine whether significant biological differences exist among the HIV-2 subtypes.

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