Nicotine attenuates relapse to methamphetamine-seeking behavior (craving) in rats

Takato Hiranita, Kusnandar Anggadiredja, Chie Fujisaki, Shigenori Watanabe, Tsuneyuki Yamamoto

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


This study clarifies the modulating action of the nicotinic cholinergic system on reinstatement of methamphetamine (MAP)-seeking behavior (craving) using an intravenous, self-administration paradigm in rats. After self-administration of MAP for 10 days, replacing MAP with saline solution (MAP withdrawal) gradually decreased lever-pressing responses. On the sixth day of MAP withdrawal, MAP (1.0 mg/kg, i.p.)-priming injection significantly increased lever-pressing responses (reinstatement of MAP-seeking behavior). This MAP-seeking behavior was attenuated by repeated nicotine administration for 5 days during MAP withdrawal, and this attenuating effect was antagonized by the nicotinic antagonist mecamylamine. These results suggest that the appearance of MAP-seeking behavior may be due to inactivation of the nicotinic cholinergic neuron. Furthermore, it is suggested that nicotinic activating agents may be useful in preventing relapse to drug abuse.

Original languageEnglish (US)
Pages (from-to)504-507
Number of pages4
JournalAnnals of the New York Academy of Sciences
StatePublished - 2004
Externally publishedYes


  • Drug-seeking behavior
  • Methamphetamine
  • Nicotine
  • Priming
  • Reinstatement
  • Self-administration

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Neuroscience
  • History and Philosophy of Science


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