NIA Interventions Testing Program: A collaborative approach for investigating interventions to promote healthy aging

Francesca Macchiarini, Richard A. Miller, Randy Strong, Nadia Rosenthal, David E. Harrison

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The NIA Interventions Testing Program (ITP) investigates the potential of dietary interventions to promote healthy aging and provides preliminary data on cellular mechanisms and pathways that affect aging. Members of the research community propose compounds for study, and lifespan and health studies are performed at three sites to demonstrate the degree of reproducibility. A genetically heterogeneous mouse model is used to reduce the influence of strain-specific characteristics on the outcomes, and sufficient mice are used to detect a 10% change in mean lifespan with 80% power if at least two sites contribute data. There have been several positive findings that have prompted additional studies within the ITP and from the broader research community, including data on rapamycin, acarbose, 17α-estradiol, nordihydroguaiaretic acid, Protandim, and glycine. This chapter describes the ITP structure, summarizes findings to date and how they have led to additional studies, and discusses the future role of the ITP in promoting research on antiaging interventions.

Original languageEnglish (US)
Title of host publicationHandbook of the Biology of Aging
PublisherElsevier
Pages219-235
Number of pages17
ISBN (Electronic)9780128159620
DOIs
StatePublished - Jan 1 2021

Keywords

  • Health
  • Heterogeneous mice
  • Lifespan
  • Longevity

ASJC Scopus subject areas

  • Social Sciences(all)

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