NF-κB activation is not required for Chlamydia trachomatis inhibition of host epithelial cell apoptosis

Yangming Xiao, Youmin Zhong, Heng Su, Zhiguang Zhou, Paul Chiao, Guangming Zhong

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Chlamydia trachomatis, an obligate intracellular bacterial species, is known to inhibit host cell apoptosis. However, the chlamydial antiapoptotic mechanism is still not clear. Because NF-κB activation is antiapoptotic, we tested the potential role of NF-κB activation in chlamydial antiapoptotic activity in the current study. First, no obvious NF-κB activation was detected in the chlamydia-infected cells when these cells were resistant to apoptosis induced via either the intrinsic or extrinsic apoptosis pathways. Second, inhibition of NF-κB activation with pharmacologic reagents failed to block the chlamydial antiapoptotic activity. Finally, NF-κB p65 gene deletion did not prevent chlamydia from inhibiting host cell apoptosis. These observations together have demonstrated that NF-κB activation is not required for the chlamydial antiapoptotic activity.

Original languageEnglish (US)
Pages (from-to)1701-1708
Number of pages8
JournalJournal of Immunology
Volume174
Issue number3
DOIs
StatePublished - Feb 1 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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