TY - JOUR
T1 - NF-κB activation is not required for Chlamydia trachomatis inhibition of host epithelial cell apoptosis
AU - Xiao, Yangming
AU - Zhong, Youmin
AU - Su, Heng
AU - Zhou, Zhiguang
AU - Chiao, Paul
AU - Zhong, Guangming
PY - 2005/2/1
Y1 - 2005/2/1
N2 - Chlamydia trachomatis, an obligate intracellular bacterial species, is known to inhibit host cell apoptosis. However, the chlamydial antiapoptotic mechanism is still not clear. Because NF-κB activation is antiapoptotic, we tested the potential role of NF-κB activation in chlamydial antiapoptotic activity in the current study. First, no obvious NF-κB activation was detected in the chlamydia-infected cells when these cells were resistant to apoptosis induced via either the intrinsic or extrinsic apoptosis pathways. Second, inhibition of NF-κB activation with pharmacologic reagents failed to block the chlamydial antiapoptotic activity. Finally, NF-κB p65 gene deletion did not prevent chlamydia from inhibiting host cell apoptosis. These observations together have demonstrated that NF-κB activation is not required for the chlamydial antiapoptotic activity.
AB - Chlamydia trachomatis, an obligate intracellular bacterial species, is known to inhibit host cell apoptosis. However, the chlamydial antiapoptotic mechanism is still not clear. Because NF-κB activation is antiapoptotic, we tested the potential role of NF-κB activation in chlamydial antiapoptotic activity in the current study. First, no obvious NF-κB activation was detected in the chlamydia-infected cells when these cells were resistant to apoptosis induced via either the intrinsic or extrinsic apoptosis pathways. Second, inhibition of NF-κB activation with pharmacologic reagents failed to block the chlamydial antiapoptotic activity. Finally, NF-κB p65 gene deletion did not prevent chlamydia from inhibiting host cell apoptosis. These observations together have demonstrated that NF-κB activation is not required for the chlamydial antiapoptotic activity.
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U2 - 10.4049/jimmunol.174.3.1701
DO - 10.4049/jimmunol.174.3.1701
M3 - Article
C2 - 15661934
AN - SCOPUS:12444338487
SN - 0022-1767
VL - 174
SP - 1701
EP - 1708
JO - Journal of Immunology
JF - Journal of Immunology
IS - 3
ER -