Newborn Screening System Performance Evaluation Assessment Scheme (PEAS)

Bradford L. Therrell, Marion Schwartz, Carol Southard, Donna Williams, W. Harry Hannon, Marie Y. Mann

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Newborn screening (NBS) reaches approximately all of the 4 million newborns in the United States each year and has been effective in significantly reducing the morbidity and mortality that results from certain congenital conditions. The comprehensive NBS system can be divided into preanalytic (education and screening), analytic (laboratory testing), and postanalytic (reporting, short-term follow-up/tracking, diagnosis, treatment/management, ancillary services, and outcome evaluation) activities. To monitor and improve the screening system, there has been increasing emphasis on evaluation models. Federal sponsorship of a model performance evaluation and assessment scheme (PEAS) has resulted in a comprehensive listing of quality indicators for system self-assessment. We review the PEAS evolution process in an effort to illustrate the necessary infrastructure considerations in a well-functioning NBS system. Readers are encouraged to identify their role in the system and to interact appropriately at the local level. The comprehensive PEAS indicator list is provided as an Appendix.

Original languageEnglish (US)
Pages (from-to)105-120
Number of pages16
JournalSeminars in Perinatology
Issue number2
StatePublished - Apr 2010


  • indicators
  • newborn screening
  • performance
  • quality assurance
  • system

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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