Newborn screening for sickle cell diseases in the United States: A review of data spanning 2 decades

Bradford L. Therrell, Michele A. Lloyd-Puryear, James R. Eckman, Marie Y. Mann

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations


Sickle cell disease is a group of disorders, the majority of which are detected through state newborn screening programs. There is limited knowledge of disease prevalence in the U.S. population. We report 20 years of case finding and laboratory data for sickle cell disease and trait to assist in: planning for health services delivery; providing data for researchers; aiding in tracking health outcome trends; and assessing sickle gene prevalence in the newborn population. During the 20-year period, there were 39,422 confirmed cases of sickle cell disease among 76,527,627 newborn births screened (1:1941) and 1,107,875 laboratory reports of probable sickle trait among 73,951,175 newborn births screened (1:67). The highest sickle cell disease incidence during the 20 years was in the District of Columbia (1:437) followed by Mississippi (1:683) and South Carolina (1:771). For sickle cell trait, the highest incidences were in the District of Columbia (1:22), Mississippi (1:26), and South Carolina (1:31).

Original languageEnglish (US)
Pages (from-to)238-251
Number of pages14
JournalSeminars in Perinatology
Issue number3
StatePublished - Apr 1 2015


  • National data
  • Newborn screening
  • Sickle cell disease
  • Sickle cell trait

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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