Abstract
Shen et al. exploit glycobiology to dampen transforming growth factor-β (TGF-β) signaling and ameliorate renal fibrosis after ureteral obstruction. Core fucosylation of N-linked oligosaccharides in TGF-β receptors is required for receptor function. Adenoviruses expressing Fut8-fucosyl transferase-shRNA inhibited receptor fucosylation, decreased tubule TGF-β signaling, and reduced fibrosis. Fut8-shRNA interferes with core fucosylation of other receptors also. Regardless, this first attempt to capitalize on a new aspect of TGF-β receptor function provides a basis for further research.
Original language | English (US) |
---|---|
Pages (from-to) | 11-14 |
Number of pages | 4 |
Journal | Kidney international |
Volume | 84 |
Issue number | 1 |
DOIs |
|
State | Published - Jul 2013 |
ASJC Scopus subject areas
- Nephrology