New wrinkles in old receptors: Core fucosylation is yet another target to inhibit TGF-β signaling

Manjeri A. Venkatachalam, Joel M. Weinberg

Research output: Contribution to journalComment/debate

13 Scopus citations

Abstract

Shen et al. exploit glycobiology to dampen transforming growth factor-β (TGF-β) signaling and ameliorate renal fibrosis after ureteral obstruction. Core fucosylation of N-linked oligosaccharides in TGF-β receptors is required for receptor function. Adenoviruses expressing Fut8-fucosyl transferase-shRNA inhibited receptor fucosylation, decreased tubule TGF-β signaling, and reduced fibrosis. Fut8-shRNA interferes with core fucosylation of other receptors also. Regardless, this first attempt to capitalize on a new aspect of TGF-β receptor function provides a basis for further research.

Original languageEnglish (US)
Pages (from-to)11-14
Number of pages4
JournalKidney international
Volume84
Issue number1
DOIs
StatePublished - Jul 2013

ASJC Scopus subject areas

  • Nephrology

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