New strategies for treating AIDS

Paul A. Sandstrom, Thomas M. Folks

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To date, the effective management of HIV-1 infection by anti-retroviral drugs has proved remarkably difficult to achieve. This is primarily due to the ease with which HIV-1 becomes resistant to drugs which initially may be very effective at blocking viral replication. In a recent issue of Science, two promising new AIDS treatments were reported. The first described the use of retroviral-type zinc finger structures found in the HIV-1 nucleocapsid protein as targets for antiretroviral drugs(1). The second demonstrated the feasibility of the reverse transcriptase inhibitor (R)-9-(2-phosphonylmethoxypropyl) adenine as a postexposure prophylaxis in blocking HIV-1 infection(2).

Original languageEnglish (US)
Pages (from-to)343-346
Number of pages4
JournalBioEssays
Volume18
Issue number5
StatePublished - 1996
Externally publishedYes

Fingerprint

Human immunodeficiency virus 1
HIV-1
Acquired Immunodeficiency Syndrome
Tenofovir
Pharmaceutical Preparations
HIV Infections
Nucleocapsid Proteins
Reverse Transcriptase Inhibitors
nucleocapsid proteins
Zinc
RNA-directed DNA polymerase
zinc finger motif
Zinc Fingers
adenine
virus replication
infection
disease control
drugs
antiretroviral agents

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology
  • Developmental Biology
  • Neuroscience (miscellaneous)

Cite this

Sandstrom, P. A., & Folks, T. M. (1996). New strategies for treating AIDS. BioEssays, 18(5), 343-346.

New strategies for treating AIDS. / Sandstrom, Paul A.; Folks, Thomas M.

In: BioEssays, Vol. 18, No. 5, 1996, p. 343-346.

Research output: Contribution to journalArticle

Sandstrom, PA & Folks, TM 1996, 'New strategies for treating AIDS', BioEssays, vol. 18, no. 5, pp. 343-346.
Sandstrom PA, Folks TM. New strategies for treating AIDS. BioEssays. 1996;18(5):343-346.
Sandstrom, Paul A. ; Folks, Thomas M. / New strategies for treating AIDS. In: BioEssays. 1996 ; Vol. 18, No. 5. pp. 343-346.
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