Abstract
To date, the effective management of HIV-1 infection by anti-retroviral drugs has proved remarkably difficult to achieve. This is primarily due to the ease with which HIV-1 becomes resistant to drugs which initially may be very effective at blocking viral replication. In a recent issue of Science, two promising new AIDS treatments were reported. The first described the use of retroviral-type zinc finger structures found in the HIV-1 nucleocapsid protein as targets for antiretroviral drugs(1). The second demonstrated the feasibility of the reverse transcriptase inhibitor (R)-9-(2-phosphonylmethoxypropyl) adenine as a postexposure prophylaxis in blocking HIV-1 infection(2).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 343-346 |
| Number of pages | 4 |
| Journal | BioEssays |
| Volume | 18 |
| Issue number | 5 |
| State | Published - 1996 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Plant Science
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Cell Biology
- Developmental Biology
- Neuroscience (miscellaneous)
Cite this
New strategies for treating AIDS. / Sandstrom, Paul A.; Folks, Thomas M.
In: BioEssays, Vol. 18, No. 5, 1996, p. 343-346.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New strategies for treating AIDS
AU - Sandstrom, Paul A.
AU - Folks, Thomas M.
PY - 1996
Y1 - 1996
N2 - To date, the effective management of HIV-1 infection by anti-retroviral drugs has proved remarkably difficult to achieve. This is primarily due to the ease with which HIV-1 becomes resistant to drugs which initially may be very effective at blocking viral replication. In a recent issue of Science, two promising new AIDS treatments were reported. The first described the use of retroviral-type zinc finger structures found in the HIV-1 nucleocapsid protein as targets for antiretroviral drugs(1). The second demonstrated the feasibility of the reverse transcriptase inhibitor (R)-9-(2-phosphonylmethoxypropyl) adenine as a postexposure prophylaxis in blocking HIV-1 infection(2).
AB - To date, the effective management of HIV-1 infection by anti-retroviral drugs has proved remarkably difficult to achieve. This is primarily due to the ease with which HIV-1 becomes resistant to drugs which initially may be very effective at blocking viral replication. In a recent issue of Science, two promising new AIDS treatments were reported. The first described the use of retroviral-type zinc finger structures found in the HIV-1 nucleocapsid protein as targets for antiretroviral drugs(1). The second demonstrated the feasibility of the reverse transcriptase inhibitor (R)-9-(2-phosphonylmethoxypropyl) adenine as a postexposure prophylaxis in blocking HIV-1 infection(2).
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UR - http://www.scopus.com/inward/citedby.url?scp=0030137992&partnerID=8YFLogxK
M3 - Article
C2 - 8639156
AN - SCOPUS:0030137992
VL - 18
SP - 343
EP - 346
JO - BioEssays
JF - BioEssays
SN - 0265-9247
IS - 5
ER -