TY - JOUR
T1 - New n-nonadecanoyl-β-sitosterol and other constituents from the stem-bark of Anacardium occidentale
AU - Shehu, Abdullahi
AU - Ponnapalli, Mangala Gowri
AU - Mahboob, M.
AU - Prabhakar, P. V.
AU - Olatunji, Gabriel Ademola
N1 - Publisher Copyright:
© 2019 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - A new steroidal ester bearing n-nonadecanoyl moiety (1) and a mixture of isomeric cerebrosides (2) along with two known compounds were isolated from the methanol extract of the stem-bark of Anacardium occidentale. The structure of the new steroidal ester was determined as 3-n-nonadecanoyl-β-sitosterol on the basis of modern spectroscopic techniques (IR, ESI-MS, HR-ESIMS, 1D and 2D NMR) and chemical degradation studies. The structures of the known compounds were identified as gallic acid and tanacetene by comparison of the spectroscopic data with those of reported data. The mixture of cerebrosides was confirmed based on the analysis of 1D and 2D NMR. These compounds were evaluated for cytotoxicity against human cancer cell lines A549, SCOV3 and rat normal cell line NRK49f.
AB - A new steroidal ester bearing n-nonadecanoyl moiety (1) and a mixture of isomeric cerebrosides (2) along with two known compounds were isolated from the methanol extract of the stem-bark of Anacardium occidentale. The structure of the new steroidal ester was determined as 3-n-nonadecanoyl-β-sitosterol on the basis of modern spectroscopic techniques (IR, ESI-MS, HR-ESIMS, 1D and 2D NMR) and chemical degradation studies. The structures of the known compounds were identified as gallic acid and tanacetene by comparison of the spectroscopic data with those of reported data. The mixture of cerebrosides was confirmed based on the analysis of 1D and 2D NMR. These compounds were evaluated for cytotoxicity against human cancer cell lines A549, SCOV3 and rat normal cell line NRK49f.
KW - 3-n-nonadecanoyl-β-sitosterol
KW - Anacardium occidentale
KW - cerebroside
KW - cytotoxicity
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U2 - 10.1080/14786419.2019.1650353
DO - 10.1080/14786419.2019.1650353
M3 - Article
C2 - 31397595
AN - SCOPUS:85070841964
SN - 1478-6419
VL - 35
SP - 1357
EP - 1363
JO - Natural Product Research
JF - Natural Product Research
IS - 8
ER -