New insights on endocannabinoid transmission in psychomotor disorders

Andrea Giuffrida; Alexandre Seillier

doi:10.1016/j.pnpbp.2012.04.002

New insights on endocannabinoid transmission in psychomotor disorders

Andrea Giuffrida, Alexandre Seillier

Pharmacology

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

The endocannabinoids are lipid signaling molecules that bind to cannabinoid CB₁ and CB₂ receptors and other metabotropic and ionotropic receptors. Anandamide and 2-arachidonoyl glycerol, the two best-characterized examples, are released on demand in a stimulus-dependent manner by cleavage of membrane phospholipid precursors. Together with their receptors and metabolic enzymes, the endocannabinoids play a key role in modulating neurotransmission and synaptic plasticity in the basal ganglia and other brain areas involved in the control of motor functions and motivational aspects of behavior.This mini-review provides an update on the contribution of the endocannabinoid system to the regulation of psychomotor behaviors and its possible involvement in the pathophysiology of Parkinson's disease and schizophrenia.

Original language	English (US)
Pages (from-to)	51-58
Number of pages	8
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/j.pnpbp.2012.04.002
State	Published - Jul 2 2012

Keywords

Basal ganglia
Cannabinoid
Dyskinesia
Endocannabinoid
Parkinson
Schizophrenia

ASJC Scopus subject areas

Pharmacology
Biological Psychiatry

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