New insights on endocannabinoid transmission in psychomotor disorders

Andrea Giuffrida, Alexandre Seillier

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


The endocannabinoids are lipid signaling molecules that bind to cannabinoid CB1 and CB2 receptors and other metabotropic and ionotropic receptors. Anandamide and 2-arachidonoyl glycerol, the two best-characterized examples, are released on demand in a stimulus-dependent manner by cleavage of membrane phospholipid precursors. Together with their receptors and metabolic enzymes, the endocannabinoids play a key role in modulating neurotransmission and synaptic plasticity in the basal ganglia and other brain areas involved in the control of motor functions and motivational aspects of behavior.This mini-review provides an update on the contribution of the endocannabinoid system to the regulation of psychomotor behaviors and its possible involvement in the pathophysiology of Parkinson's disease and schizophrenia.

Original languageEnglish (US)
Pages (from-to)51-58
Number of pages8
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Issue number1
StatePublished - Jul 2 2012


  • Basal ganglia
  • Cannabinoid
  • Dyskinesia
  • Endocannabinoid
  • Parkinson
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry


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