TY - JOUR
T1 - New insights into gastrointestinal anthrax infection
AU - Owen, Jennifer L.
AU - Yang, Tao
AU - Mohamadzadeh, Mansour
N1 - Funding Information:
This work was supported in part by National Institutes of Health (NIH) Grant 1R01AI098833-01, Gatorade Seed Funds from the University of Florida, and NIH/National Center for Research Resources (NCRR) Clinical and Translational Science Award to the University of Florida (UL1 RR 029890).
Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Bacterial infections are the primary cause of gastrointestinal (GI) disorders in both developing and developed countries, and are particularly dangerous for infants and children. Bacillus anthracis is the 'archetype zoonotic' pathogen; no other infectious disease affects such a broad range of species, including humans. Importantly, there are more case reports of GI anthrax infection in children than inhalational disease. Early diagnosis is difficult and widespread systemic disease develops rapidly. This review highlights new findings concerning the roles of the gut epithelia, commensal microbiota, and innate lymphoid cells (ILCs) in initiation of disease and systemic dissemination in animal models of GI anthrax, the understanding of which is crucial to designing alternative therapies that target the establishment of infection.
AB - Bacterial infections are the primary cause of gastrointestinal (GI) disorders in both developing and developed countries, and are particularly dangerous for infants and children. Bacillus anthracis is the 'archetype zoonotic' pathogen; no other infectious disease affects such a broad range of species, including humans. Importantly, there are more case reports of GI anthrax infection in children than inhalational disease. Early diagnosis is difficult and widespread systemic disease develops rapidly. This review highlights new findings concerning the roles of the gut epithelia, commensal microbiota, and innate lymphoid cells (ILCs) in initiation of disease and systemic dissemination in animal models of GI anthrax, the understanding of which is crucial to designing alternative therapies that target the establishment of infection.
KW - B-1 cells
KW - Bacillus anthracis
KW - Gastrointestinal anthrax
KW - Infectious enteritis
KW - Innate lymphoid cells
KW - Microbiota
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U2 - 10.1016/j.molmed.2014.12.003
DO - 10.1016/j.molmed.2014.12.003
M3 - Review article
C2 - 25577136
AN - SCOPUS:84924616217
SN - 1471-4914
VL - 21
SP - 154
EP - 163
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 3
ER -