Neue erkenntnisse zur chemoprävention des prostatakarzinoms

Translated title of the contribution: New insights into chemoprevention of prostate cancer

B. Djavan, I. Thompson, M. Waldert, M. S. Michel, C. Seitz

Research output: Contribution to journalReview article

Abstract

Despite advances in the detection and management of prostate cancer, this disease remains a major cause of morbidity and mortality in men. Increasing attention has focused on the role of chemoprevention for prostate cancer, i.e., the administration of agents that inhibit one or more steps in the natural course of prostate carcinogenesis. We review prostate cancer chemoprevention studies in Europe. Published studies were identified in a search of MEDLINE. Information about ongoing studies was provided by author access to protocols. A variety of chemoprevention studies have focused on the role of dietary factors, vitamins, and trace elements in prostate cancer. Some of these studies have been prospective, randomized, and double-blinded, while others have used retrospective or epidemiological approaches. Large-scale randomized studies are also evaluating the role of 5α-reductase inhibitors, which inhibit the conversion of testosterone to the more potent androgen dihydrotestosterone. Robust evidence is lacking for the value of chemopreventive agents in prostate cancer. Current evidence does suggest that vitamin E and selenium may have a role in prostate cancer chemoprevention. Data from two studies, one examining the type 1 5α-reductase selective inhibitor finasteride and the other using the dual 5α-reductase inhibitor dutasteride, will determine the benefits of androgen inhibition strategies for prostate cancer chemoprevention.

Original languageGerman
Pages (from-to)642-646
Number of pages5
JournalOnkologe
Volume10
Issue number6
StatePublished - Jun 1 2004

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Keywords

  • 5α-reductase inhibitors
  • Chemoprevention studies
  • Dietary composition
  • Dutasteride
  • Finasteride

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Djavan, B., Thompson, I., Waldert, M., Michel, M. S., & Seitz, C. (2004). Neue erkenntnisse zur chemoprävention des prostatakarzinoms. Onkologe, 10(6), 642-646.