New HIV type 1 CRF01_AE/B recombinants displaying unique distribution of breakpoints from incident infections among injecting drug users in Thailand

Artur Ramos, Shambavi Subbarao, Lily Nguyen, Dale J. Hu, Suphak Vanichseni, Kachit Choopanya, Nancy L. Young, Jordan W. Tappero, Timothy D. Mastro, Thomas M. Folks

    Research output: Contribution to journalArticlepeer-review

    28 Scopus citations

    Abstract

    The goals of this study were to identify and characterize recombinant human immunodeficiency virus type 1 (HIV-1) genomes among incident infections in a prospective cohort study of injecting drug users (IDUs) in Bangkok, Thailand. Through cross-sectional, comparative phylogenetic analysis of the protease and env (C2-V4) gene regions, subtype discordance was observed in HIV-1 sequences from 4 of 111 IDUs (3.5%). Near-full-length HIV-1 genome sequences of the four strains revealed that in all four, the gp120 sequences clustered with a CRF01_AE prototype, while the remainder of the genomes displayed distinct mosaic patterns, with multiple breakpoints between HIV-1 CRF01_AE and subtype B-like regions. Two of the four HIV-1 recombinant strains displayed a nearly identical mosaic structure, suggesting the possible emergence and spread of a potentially new circulating recombinant form of HIV-1. Further characterization of these and other recombinant genomes through long-term follow-up will be important in understanding the generation of viral diversity and escape from the host?s immune responses. This information will be especially important for vaccine development.

    Original languageEnglish (US)
    Pages (from-to)667-674
    Number of pages8
    JournalAIDS Research and Human Retroviruses
    Volume19
    Issue number8
    DOIs
    StatePublished - Aug 1 2003

    ASJC Scopus subject areas

    • Immunology
    • Virology
    • Infectious Diseases

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