New guinea pig model of cryptococcal meningitis

William R. Kirkpatrick; Laura K. Najvar; Rosie Bocanegra; Thomas F. Patterson; John R. Graybill

doi:10.1128/AAC.00085-07

New guinea pig model of cryptococcal meningitis

William R. Kirkpatrick, Laura K. Najvar, Rosie Bocanegra, Thomas F. Patterson, John R. Graybill

Division of Infectious Diseases

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

We developed a guinea pig model of cryptococcal meningitis to evaluate antifungal agents. Immunosuppressed animals challenged intracranially with Cryptococcus neoformans responded to fluconazole and voriconazole. Disease was monitored by serial cerebrospinal fluid (CSF) cultures and quantitative organ cultures. Our model produces disseminating central nervous system disease and responds to antifungal therapy.

Original language	English (US)
Pages (from-to)	3011-3013
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	51
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00085-07
State	Published - Aug 2007

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

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title = "New guinea pig model of cryptococcal meningitis",

abstract = "We developed a guinea pig model of cryptococcal meningitis to evaluate antifungal agents. Immunosuppressed animals challenged intracranially with Cryptococcus neoformans responded to fluconazole and voriconazole. Disease was monitored by serial cerebrospinal fluid (CSF) cultures and quantitative organ cultures. Our model produces disseminating central nervous system disease and responds to antifungal therapy.",

author = "Kirkpatrick, {William R.} and Najvar, {Laura K.} and Rosie Bocanegra and Patterson, {Thomas F.} and Graybill, {John R.}",

year = "2007",

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AU - Patterson, Thomas F.

AU - Graybill, John R.

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AB - We developed a guinea pig model of cryptococcal meningitis to evaluate antifungal agents. Immunosuppressed animals challenged intracranially with Cryptococcus neoformans responded to fluconazole and voriconazole. Disease was monitored by serial cerebrospinal fluid (CSF) cultures and quantitative organ cultures. Our model produces disseminating central nervous system disease and responds to antifungal therapy.

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New guinea pig model of cryptococcal meningitis

Abstract

ASJC Scopus subject areas

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