New guinea pig model of cryptococcal meningitis

William R. Kirkpatrick, Laura K. Najvar, Rosie Bocanegra, Thomas F. Patterson, John R. Graybill

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19 Scopus citations

Abstract

We developed a guinea pig model of cryptococcal meningitis to evaluate antifungal agents. Immunosuppressed animals challenged intracranially with Cryptococcus neoformans responded to fluconazole and voriconazole. Disease was monitored by serial cerebrospinal fluid (CSF) cultures and quantitative organ cultures. Our model produces disseminating central nervous system disease and responds to antifungal therapy.

Original languageEnglish (US)
Pages (from-to)3011-3013
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number8
DOIs
Publication statusPublished - Aug 1 2007

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Kirkpatrick, W. R., Najvar, L. K., Bocanegra, R., Patterson, T. F., & Graybill, J. R. (2007). New guinea pig model of cryptococcal meningitis. Antimicrobial agents and chemotherapy, 51(8), 3011-3013. https://doi.org/10.1128/AAC.00085-07