New generation of oral mucosal vaccines targeting dendritic cells

Jennifer L. Owen, Bikash Sahay, Mansour Mohamadzadeh

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

As most infectious organisms gain entry at mucosal surfaces, there is a great deal of interest in developing vaccines that elicit effective mucosal immune responses against pathogen challenge. Targeted vaccination is one of the most effective methods available to prevent and control infectious diseases. Mucosal vaccines can offer lower costs, better accessibility, needle free delivery, and a higher capacity for mass immunizations during pandemics. Both local mucosal immunity and robust systemic responses can be achieved through mucosal vaccination. Recent progress in understanding the molecular and cellular components of the mucosal immune system have allowed for the development of a novel mucosal vaccine platform utilizing specific dendritic cell-targeting peptides and orally administered lactobacilli to elicit efficient antigen specific immune responses against infections, including Bacillus anthracis in experimental models of disease.

Original languageEnglish (US)
Pages (from-to)918-924
Number of pages7
JournalCurrent Opinion in Chemical Biology
Volume17
Issue number6
DOIs
StatePublished - Dec 2013
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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