New directions for studying the role of free radicals in aging

M. A. Pahlavani, H. Van Remmen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Oxidative damage caused by free radicals in vivo is believed to play an important role in the etiology of aging and age-associated degenerative diseases. The most direct evidence supporting this theory is the recent finding that the transgenic Drosophila that overexpress the antioxidant enzymes catalase and superoxide dismutase exhibit an increase in life span. Although the increase in life span in Drosophila by these enzymes is certainly important, the next logical direction is to demonstrate whether increased antioxidant protection occurs similarly in mammals. Several transgenic mouse models that overexpress antioxidant enzymes are currently available. However, one major shortcoming in using these transgenic mice is the difficulty of producing antioxidant overexpression in more than a few tissues. Despite the potential shortcomings of using transgenic mice, these animals provide a unique system in which individual components of a complex system, such as the antioxidant defense system, can be modulated and examined independently. Transgenic mice are therefore potentially powerful tools to study the role of various components of the antioxidant system in the aging process. A parallel direction in the study of free radical roles in aging is to investigate the modulation of transcription factors by oxidative stress. Among these, the transcription factors, NF-≃B and AP-1 are implicated in oxidative stress. The activities of these oxidative stress-response transcription factors are regulated by upstream signaling molecules, which involve a cascade of phosphorylation and dephosphorylation events leading to their activation. In this article, we review recent studies that use molecular approaches to investigate the biological role of oxidant stress. Each of these studies potentially provide new insights into the roles of free radicals and free radical damage in the aging process.

Original languageEnglish (US)
Pages (from-to)151-163
Number of pages13
JournalAge
Volume20
Issue number3
StatePublished - 1997

Fingerprint

Free Radicals
Antioxidants
Transgenic Mice
Oxidative Stress
Transcription Factors
Drosophila
Enzymes
Genetically Modified Animals
Transcription Factor AP-1
Oxidants
Catalase
Superoxide Dismutase
Direction compound
Mammals
Phosphorylation

Keywords

  • Antioxidant defense
  • Overexpression and deletion of genes
  • Oxidative stress
  • Signal transduction
  • Transcription factors
  • Transgenic mice

ASJC Scopus subject areas

  • Aging

Cite this

Pahlavani, M. A., & Van Remmen, H. (1997). New directions for studying the role of free radicals in aging. Age, 20(3), 151-163.

New directions for studying the role of free radicals in aging. / Pahlavani, M. A.; Van Remmen, H.

In: Age, Vol. 20, No. 3, 1997, p. 151-163.

Research output: Contribution to journalArticle

Pahlavani, MA & Van Remmen, H 1997, 'New directions for studying the role of free radicals in aging', Age, vol. 20, no. 3, pp. 151-163.
Pahlavani MA, Van Remmen H. New directions for studying the role of free radicals in aging. Age. 1997;20(3):151-163.
Pahlavani, M. A. ; Van Remmen, H. / New directions for studying the role of free radicals in aging. In: Age. 1997 ; Vol. 20, No. 3. pp. 151-163.
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