New developments in multidimensional mass spectrometry based shotgun lipidomics

Xianlin Han, Richard W. Gross

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Shotgun lipidomics, as one of the approaches employed for lipidomics analysis based on ESI/MS, is getting more and more developed. At the current stage of development for shotgun lipidomics, the analyses of over 20 lipid classes, hundreds to over a thousand lipid molecular species, and >95% of the mass content of a cellular lipidome can be readily achieved. Even at this stage, shotgun lipidomics has already showed its powerful and broad applications in biological, pathological, and pathophysiological studies.38,52-57 It can be anticipated that identification of many biochemical mechanisms underlying lipid metabolism critical to disease states will be increasingly uncovered as the further development of shotgun lipidomics and its penetration into lower and lower abundance regions of mass contents of individual lipid molecular species.

Original languageEnglish (US)
Title of host publicationMetabolomics, Metabonomics and Metabolite Profiling
EditorsWilliam Griffiths
Pages134-160
Number of pages27
StatePublished - Dec 1 2007
Externally publishedYes

Publication series

NameRSC Biomolecular Sciences
ISSN (Print)1757-7152
ISSN (Electronic)1757-7160

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ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Molecular Biology

Cite this

Han, X., & Gross, R. W. (2007). New developments in multidimensional mass spectrometry based shotgun lipidomics. In W. Griffiths (Ed.), Metabolomics, Metabonomics and Metabolite Profiling (pp. 134-160). (RSC Biomolecular Sciences).