"New"-clear functions of PDK1: Beyond a master kinase in the cytosol?

Chintan K. Kikani, Lily Q. Dong, Feng Liu

Research output: Contribution to journalReview article

49 Scopus citations

Abstract

Activation of cytosolic phosphoinositide-3 kinase (PI-3K) signaling pathway has been well established to regulate gene expression, cell cycle, and survival by feeding signals to the nucleus. In addition, strong evidences accumulated over the past few years indicate the presence of an autonomous inositol lipid metabolism and PI-3K signaling within the nucleus. Much less, however, is known about the role and regulation of this nuclear PI-3K pathway. Components of the PI-3K signaling pathway, including PI3-kinase and its downstream kinase Akt, have been identified at the nuclear level. Consistent with the presence of a complete PI-3K signaling pathway in the nucleus, we have recently found that phosphoinositide-dependent kinase 1 (PDK1), a kinase functioning downstream of PI-3K and upstream of Akt, is a nucleo-cytoplasmic shuttling protein. In the present review, we update our current knowledge on the regulatory mechanisms and the functional roles of PDK1 nuclear translocation. We also summarize some of the kinase-independent activities of PDK1 in cell signaling.

Original languageEnglish (US)
Pages (from-to)1157-1162
Number of pages6
JournalJournal of Cellular Biochemistry
Volume96
Issue number6
DOIs
StatePublished - Dec 15 2005

Keywords

  • IGF-1
  • Insulin
  • Nuclear PI-3K signaling pathway
  • PDK1
  • PIP

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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