New cellular and molecular approaches for the treatment of cardiac disease

Laurence Kedes, Robert Kloner, Kimi Kong, Coralie Poizat, Boris Simkhovich, Tatsuya Iso, Yasuo Hamamori

Research output: Contribution to journalArticlepeer-review


Similar to the kidney in uremia, end-stage cardiac failure is an outcome common to many disparate disease processes including hypertension, various inflammatory pathologies, as well as ischemic loss of tissue. In regard to the heart, cellular and molecular mechanisms responsible for heart failure have been investigated with renewed intensity over the past several years with newer techniques of molecular genetics, genomic analysis, and cell biology. Although this article reviews some recent advances made in our understanding of molecular and cellular events in the heart leading to heart failure and explores possible new targets for therapeutics, the main point is to stress the importance of investigative interactions between organ physiologists and molecular and cellular biologists. These interactions between organ physiologists and molecular geneticists is stressed and supported as a mechanism for rapid advancement for both understanding the underlying pathophysiology of human disease and the development of therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)437-440
Number of pages4
JournalSeminars in nephrology
Issue number5
StatePublished - Sep 1 2004
Externally publishedYes


  • cardiac
  • gene therapy
  • heart
  • myofilament
  • notch
  • transcription
  • tropomodulin
  • vascularization

ASJC Scopus subject areas

  • Nephrology

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