Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses

Thomas Hägglöf, Saikiran K. Sedimbi, Jennifer L. Yates, Roham Parsa, Briana Hauff Salas, Robert A. Harris, Elizabeth Leadbetter, Mikael C.I. Karlsson

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The innate responsiveness of the immune system is important not only for quick responses to pathogens but also for the initiation and shaping of the subsequent adaptive immune response. Activation via the cytokine IL-18, a product of inflammasomes, gives rise to a rapid response that includes the production of self-reactive antibodies. As increased concentrations of this cytokine are found in inflammatory diseases, we investigated the origin of the B cell response and its regulation. We identified an accumulation of B cell-helper neutrophils in the spleen that interacted with innate-type invariant natural killer T cells (iNKT cells) to regulate B cell responses. We found that neutrophil-dependent expression of the death-receptor ligand FasL by iNKT cells was needed to restrict autoantibody production. Neutrophils can thus license iNKT cells to regulate potentially harmful autoreactive B cell responses during inflammasome-driven inflammation.

Original languageEnglish (US)
Pages (from-to)1407-1414
Number of pages8
JournalNature Immunology
Volume17
Issue number12
DOIs
StatePublished - Dec 1 2016

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Natural Killer T-Cells
Licensure
Neutrophils
B-Lymphocytes
Inflammasomes
Cytokines
Death Domain Receptors
Interleukin-18
Adaptive Immunity
Autoantibodies
Immune System
Spleen
Ligands
Inflammation
Antibodies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Hägglöf, T., Sedimbi, S. K., Yates, J. L., Parsa, R., Salas, B. H., Harris, R. A., ... Karlsson, M. C. I. (2016). Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses. Nature Immunology, 17(12), 1407-1414. https://doi.org/10.1038/ni.3583

Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses. / Hägglöf, Thomas; Sedimbi, Saikiran K.; Yates, Jennifer L.; Parsa, Roham; Salas, Briana Hauff; Harris, Robert A.; Leadbetter, Elizabeth; Karlsson, Mikael C.I.

In: Nature Immunology, Vol. 17, No. 12, 01.12.2016, p. 1407-1414.

Research output: Contribution to journalArticle

Hägglöf, T, Sedimbi, SK, Yates, JL, Parsa, R, Salas, BH, Harris, RA, Leadbetter, E & Karlsson, MCI 2016, 'Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses', Nature Immunology, vol. 17, no. 12, pp. 1407-1414. https://doi.org/10.1038/ni.3583
Hägglöf T, Sedimbi SK, Yates JL, Parsa R, Salas BH, Harris RA et al. Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses. Nature Immunology. 2016 Dec 1;17(12):1407-1414. https://doi.org/10.1038/ni.3583
Hägglöf, Thomas ; Sedimbi, Saikiran K. ; Yates, Jennifer L. ; Parsa, Roham ; Salas, Briana Hauff ; Harris, Robert A. ; Leadbetter, Elizabeth ; Karlsson, Mikael C.I. / Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses. In: Nature Immunology. 2016 ; Vol. 17, No. 12. pp. 1407-1414.
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