TY - JOUR
T1 - Neutrophil mediated tumor cell cytotoxicity
T2 - role of the peroxidase system
AU - Clark, R. A.
AU - Klebanoff, S. J.
PY - 1975
Y1 - 1975
N2 - A cytotoxic effect of human neutrophils on mammalian tumor cells is demonstrated. Cytotoxicity depends on the presence of intact neutrophils, phagocytosable particles, and a halide cofactor and is inhibited by azide, cyanide, and catalase. Neutrophils from patients with myeloperoxidase (MPO) deficiency or defective H2O2 production are not cytotoxic, but activity is restored by addition of purified MPO or H2O2 respectively. The findings support a mechanism involving the phagocytosis induced extracellular release of MPO and H2O2 and their reaction with a halide cofactor to damage the target cells.
AB - A cytotoxic effect of human neutrophils on mammalian tumor cells is demonstrated. Cytotoxicity depends on the presence of intact neutrophils, phagocytosable particles, and a halide cofactor and is inhibited by azide, cyanide, and catalase. Neutrophils from patients with myeloperoxidase (MPO) deficiency or defective H2O2 production are not cytotoxic, but activity is restored by addition of purified MPO or H2O2 respectively. The findings support a mechanism involving the phagocytosis induced extracellular release of MPO and H2O2 and their reaction with a halide cofactor to damage the target cells.
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U2 - 10.1084/jem.141.6.1442
DO - 10.1084/jem.141.6.1442
M3 - Article
C2 - 165258
AN - SCOPUS:0016736754
SN - 0022-1007
VL - 141
SP - 1442
EP - 1447
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 6
ER -