Neutralizing antichlamydial activity of complement by chlamydia-secreted protease CPAF

Zhangsheng Yang, Lingli Tang, Zhiguang Zhou, Guangming Zhong

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Ascending infection by sexually transmitted Chlamydia trachomatis is required for chlamydial induction of tubal pathology. To achieve ascension, the C. trachomatis organisms may have to spread from cell to cell, which inevitably exposes the organisms to extracellular mucosal effectors such as complement factors that are known to possess strong antichlamydial activities. Here, we report that the chlamydia-secreted protease CPAF efficiently neutralized complement factor C3-dependent antichlamydial activity. The neutralization was dependent on the proteolytic activity of CPAF and correlated with the CPAF-mediated degradation of complement factor C3 and factor B. As a result, CPAF preferentially inhibited the alternative complement activation pathway. The significance and limitation of these observations were discussed.

Original languageEnglish (US)
Pages (from-to)669-674
Number of pages6
JournalMicrobes and Infection
Issue number11
StatePublished - Nov 1 2016


  • CPAF
  • Neutralization of antichlamydial activity
  • Proteolysis of complement factor C3 & factor B

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases


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