Neutralizing Antibodies to Human Interleukin 6 Reverse Hypercalcemia Associated with a Human Squamous Carcinoma

Toshiyuki Yoneda, Masamichi Nakai, Keyi Moriyama, Laura Scott, Gregory R. Mundy

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

Bone resorbing cytokines may be associated with abnormalities in bone cell function and calcium homeostasis in a number of pathological conditions. One of these cytokines is interleukin 6 (IL-6), which is a multifunctional cytokine which has been shown to be associated with increased formation of bone resorbing osteoclasts in vitro. In this report, we demonstrate that neutralizing antibodies to human IL-6 lower the blood calcium in nude mice carrying a human tumor associated with increased IL-6 production. There was no effect on blood calcium in hypercalcemic nude mice carrying tumors not associated with increased IL-6 production and normocalcemic tumor-bearing nude mice. These results suggest that increased production of IL-6 may contribute to disturbances in calcium homeostasis in some malignancies, and suggest that neutralization of IL-6 effects can lower the serum calcium in these tumors.

Original languageEnglish (US)
Pages (from-to)737-740
Number of pages4
JournalCancer Research
Volume53
Issue number4
StatePublished - Feb 1993
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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