Neutral steroid losses and cholesterol absorption in gnotobiotic baboons

Glen E. Mott; Cathey J. Roberts; Jorg W. Eichberg; Henry C. McGill; S. S. Kalter

doi:10.1016/0014-4800(76)90069-1

Neutral steroid losses and cholesterol absorption in gnotobiotic baboons

Glen E. Mott, Cathey J. Roberts, Jorg W. Eichberg, Henry C. McGill, S. S. Kalter

Department of Pathology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Two infant baboons maintained under germfree conditions showed losses of neutral sterols during intestinal transit. Losses of[4-¹⁴C]β-sitosterol during 7-day stool collection could not be attributed to methodologic losses, absorption as measured by serum radioactivity, or degradation to labeled CO₂. Percent cholesterol absorption was highest during the 12 weeks following birth and decreased to normal levels by 27 weeks of age. Serum cholesterol levels decreased rapidly when the animals were converted from a gnotobiotic to a conventional environment.

Original language	English (US)
Pages (from-to)	333-345
Number of pages	13
Journal	Experimental and Molecular Pathology
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/0014-4800(76)90069-1
State	Published - Jun 1976

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Biology
Clinical Biochemistry

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10.1016/0014-4800(76)90069-1

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title = "Neutral steroid losses and cholesterol absorption in gnotobiotic baboons",

abstract = "Two infant baboons maintained under germfree conditions showed losses of neutral sterols during intestinal transit. Losses of[4-14C]β-sitosterol during 7-day stool collection could not be attributed to methodologic losses, absorption as measured by serum radioactivity, or degradation to labeled CO2. Percent cholesterol absorption was highest during the 12 weeks following birth and decreased to normal levels by 27 weeks of age. Serum cholesterol levels decreased rapidly when the animals were converted from a gnotobiotic to a conventional environment.",

author = "Mott, {Glen E.} and Roberts, {Cathey J.} and Eichberg, {Jorg W.} and McGill, {Henry C.} and Kalter, {S. S.}",

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AU - Mott, Glen E.

AU - Roberts, Cathey J.

AU - Eichberg, Jorg W.

AU - McGill, Henry C.

AU - Kalter, S. S.

PY - 1976/6

Y1 - 1976/6

N2 - Two infant baboons maintained under germfree conditions showed losses of neutral sterols during intestinal transit. Losses of[4-14C]β-sitosterol during 7-day stool collection could not be attributed to methodologic losses, absorption as measured by serum radioactivity, or degradation to labeled CO2. Percent cholesterol absorption was highest during the 12 weeks following birth and decreased to normal levels by 27 weeks of age. Serum cholesterol levels decreased rapidly when the animals were converted from a gnotobiotic to a conventional environment.

AB - Two infant baboons maintained under germfree conditions showed losses of neutral sterols during intestinal transit. Losses of[4-14C]β-sitosterol during 7-day stool collection could not be attributed to methodologic losses, absorption as measured by serum radioactivity, or degradation to labeled CO2. Percent cholesterol absorption was highest during the 12 weeks following birth and decreased to normal levels by 27 weeks of age. Serum cholesterol levels decreased rapidly when the animals were converted from a gnotobiotic to a conventional environment.

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JO - Experimental and Molecular Pathology

JF - Experimental and Molecular Pathology

SN - 0014-4800

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Neutral steroid losses and cholesterol absorption in gnotobiotic baboons

Abstract

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