Two infant baboons maintained under germfree conditions showed losses of neutral sterols during intestinal transit. Losses of[4-14C]β-sitosterol during 7-day stool collection could not be attributed to methodologic losses, absorption as measured by serum radioactivity, or degradation to labeled CO2. Percent cholesterol absorption was highest during the 12 weeks following birth and decreased to normal levels by 27 weeks of age. Serum cholesterol levels decreased rapidly when the animals were converted from a gnotobiotic to a conventional environment.
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Molecular Biology
- Clinical Biochemistry