Neutral proteinase activity in skeletal muscle from thermally injured rats

James J. Newman, David R. Strome, Cleon W. Goodwin, Arthur D. Mason, Basil A. Pruitt

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Male Sprague-Dawley rats that received 60% total body surface, full-thickness, scald burns on the dorsum and abdomen were used in this study. Neutral proteinase and Ca2+-activated neutral proteinase activities were measured in gastrocnemius and soleus muscles at 3 and 21 days after the thermal injury. Neutral proteinase activity decreased significantly in the soleus (50%) and gastrocnemius (46%) muscles on the third postburn day. Ca2+-activated neutral proteinase was unchanged at this time. Neutral proteinase and Ca2+-activated neutral proteinase activities were unaltered at 21 days postinjury. These results may reflect a protein-sparing effect on the third postburn day which could be an early intracellular change prior to an increase in selected enzyme proteins during the hypermetabolic phase after thermal injury.

Original languageEnglish (US)
Pages (from-to)515-519
Number of pages5
JournalJournal of Surgical Research
Volume35
Issue number6
DOIs
StatePublished - Dec 1983

ASJC Scopus subject areas

  • Surgery

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