Neutral proteinase activity in skeletal muscle from thermally injured rats

James J. Newman; David R. Strome; Cleon W. Goodwin; Arthur D. Mason; Basil A. Pruitt

doi:10.1016/0022-4804(83)90041-0

Neutral proteinase activity in skeletal muscle from thermally injured rats

James J. Newman, David R. Strome, Cleon W. Goodwin, Arthur D. Mason, Basil A. Pruitt

Department of Surgery

Research output: Contribution to journal › Article › peer-review

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Abstract

Male Sprague-Dawley rats that received 60% total body surface, full-thickness, scald burns on the dorsum and abdomen were used in this study. Neutral proteinase and Ca²⁺-activated neutral proteinase activities were measured in gastrocnemius and soleus muscles at 3 and 21 days after the thermal injury. Neutral proteinase activity decreased significantly in the soleus (50%) and gastrocnemius (46%) muscles on the third postburn day. Ca²⁺-activated neutral proteinase was unchanged at this time. Neutral proteinase and Ca²⁺-activated neutral proteinase activities were unaltered at 21 days postinjury. These results may reflect a protein-sparing effect on the third postburn day which could be an early intracellular change prior to an increase in selected enzyme proteins during the hypermetabolic phase after thermal injury.

Original language	English (US)
Pages (from-to)	515-519
Number of pages	5
Journal	Journal of Surgical Research
Volume	35
Issue number	6
DOIs	https://doi.org/10.1016/0022-4804(83)90041-0
State	Published - Dec 1983

ASJC Scopus subject areas

Surgery

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10.1016/0022-4804(83)90041-0

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title = "Neutral proteinase activity in skeletal muscle from thermally injured rats",

abstract = "Male Sprague-Dawley rats that received 60% total body surface, full-thickness, scald burns on the dorsum and abdomen were used in this study. Neutral proteinase and Ca2+-activated neutral proteinase activities were measured in gastrocnemius and soleus muscles at 3 and 21 days after the thermal injury. Neutral proteinase activity decreased significantly in the soleus (50%) and gastrocnemius (46%) muscles on the third postburn day. Ca2+-activated neutral proteinase was unchanged at this time. Neutral proteinase and Ca2+-activated neutral proteinase activities were unaltered at 21 days postinjury. These results may reflect a protein-sparing effect on the third postburn day which could be an early intracellular change prior to an increase in selected enzyme proteins during the hypermetabolic phase after thermal injury.",

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T1 - Neutral proteinase activity in skeletal muscle from thermally injured rats

AU - Newman, James J.

AU - Strome, David R.

AU - Goodwin, Cleon W.

AU - Mason, Arthur D.

AU - Pruitt, Basil A.

PY - 1983/12

Y1 - 1983/12

N2 - Male Sprague-Dawley rats that received 60% total body surface, full-thickness, scald burns on the dorsum and abdomen were used in this study. Neutral proteinase and Ca2+-activated neutral proteinase activities were measured in gastrocnemius and soleus muscles at 3 and 21 days after the thermal injury. Neutral proteinase activity decreased significantly in the soleus (50%) and gastrocnemius (46%) muscles on the third postburn day. Ca2+-activated neutral proteinase was unchanged at this time. Neutral proteinase and Ca2+-activated neutral proteinase activities were unaltered at 21 days postinjury. These results may reflect a protein-sparing effect on the third postburn day which could be an early intracellular change prior to an increase in selected enzyme proteins during the hypermetabolic phase after thermal injury.

AB - Male Sprague-Dawley rats that received 60% total body surface, full-thickness, scald burns on the dorsum and abdomen were used in this study. Neutral proteinase and Ca2+-activated neutral proteinase activities were measured in gastrocnemius and soleus muscles at 3 and 21 days after the thermal injury. Neutral proteinase activity decreased significantly in the soleus (50%) and gastrocnemius (46%) muscles on the third postburn day. Ca2+-activated neutral proteinase was unchanged at this time. Neutral proteinase and Ca2+-activated neutral proteinase activities were unaltered at 21 days postinjury. These results may reflect a protein-sparing effect on the third postburn day which could be an early intracellular change prior to an increase in selected enzyme proteins during the hypermetabolic phase after thermal injury.

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Neutral proteinase activity in skeletal muscle from thermally injured rats

Abstract

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