Neuropsychological deficits among patients with late-onset minor and major depression

Virginia Elderkin-Thompson, Anand Kumar, Warren B. Bilker, Jennifer J. Dunkin, Jim Mintz, Paul J. Moberg, Raquelle I. Mesholam, Ruben E. Gur

Research output: Contribution to journalArticle

128 Scopus citations

Abstract

Cognitive ability of minor depressed patients (N=28), major depressed patients (N=26) and healthy elderly (N=38) was examined cross-sectionally to determine if cognitive abilities of patients with late-onset depression decrease with increasing severity of disease and if cognitive scores for minor depressed patients fall between those of healthy elderly and major depressed patients. A pooled within-group principal component analysis of cognitive test scores identified five components, three of which showed significant group differences. Verbal Recall and Maintenance of Set separated controls from major depressed patients and minor from major depressed patients. Executive Functioning separated controls from minor depressed patients, and Working Memory was borderline for separating controls from major depressed patients. The component representing Nonverbal Recognition was not statistically significant. Partial correlations controlling for age and education indicate that cognitive performance does decrease as severity of depression increases, and the magnitude of the change varies from a trend to a significant deficit depending on the cognitive domain. This decline in cognitive performance parallels a similar trend observed in neuroanatomical studies in which the volume of the frontal and temporal lobes decrease with increasing severity of depression.

Original languageEnglish (US)
Pages (from-to)529-549
Number of pages21
JournalArchives of Clinical Neuropsychology
Volume18
Issue number5
DOIs
StatePublished - Jun 2003
Externally publishedYes

Keywords

  • Cognition
  • Depression
  • Elderly
  • Executive
  • Late-onset
  • Minor

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Clinical Psychology
  • Psychiatry and Mental health

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  • Cite this

    Elderkin-Thompson, V., Kumar, A., Bilker, W. B., Dunkin, J. J., Mintz, J., Moberg, P. J., Mesholam, R. I., & Gur, R. E. (2003). Neuropsychological deficits among patients with late-onset minor and major depression. Archives of Clinical Neuropsychology, 18(5), 529-549. https://doi.org/10.1016/S0887-6177(03)00022-2