Neuropsychological aspects of coinfection with HIV and hepatitis C virus

Robin C. Hilsabeck, Steven A. Castellon, Charles H. Hinkin

Research output: Contribution to journalReview article

55 Scopus citations

Abstract

Infection with hepatitis C virus (HCV) is commonly seen in persons with human immunodeficiency virus (HIV) infection, because the viruses share risk factors for transmission; coinfection is a leading cause of morbidity and mortality among HIV-infected persons. Neuropsychological consequences of HIV infection are well established, and studies of HCV-infected persons have revealed neuropsychiatric dysfunction in this population as well. Investigators now are focusing on neuropsychological sequelae of coinfection with HIV and HCV, and preliminary results suggest that coinfection has a possible deleterious effect on global cognitive functioning consistent with frontal-subcortical dysfunction. Data on neuropsychiatric symptoms in coinfected persons are inconclusive at this time and are complicated by important differences in study populations (e.g., injection drug use and disease severity). This review summarizes what is known about neuropsychological aspects of monoinfection with HIV and HCV, as well as coinfection, discusses implications of these findings, and suggests future directions for this research area.

Original languageEnglish (US)
Pages (from-to)S38-S44
JournalClinical Infectious Diseases
Volume41
Issue number1 SUPPL.
DOIs
StatePublished - Jul 1 2005

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Hilsabeck, R. C., Castellon, S. A., & Hinkin, C. H. (2005). Neuropsychological aspects of coinfection with HIV and hepatitis C virus. Clinical Infectious Diseases, 41(1 SUPPL.), S38-S44. https://doi.org/10.1086/429494