Neuronal input triggers Ca2+ influx through AMPA receptors and voltage-gated Ca2+ channels in oligodendrocytes

Tara Barron, Jun Hee Kim

Research output: Contribution to journalArticle

Abstract

Communication between neurons and developing oligodendrocytes (OLs) leading to OL Ca2+ rise is critical for axon myelination and OL development. Here, we investigate signaling factors and sources of Ca2+ rise in OLs in the mouse brainstem. Glutamate puff or axon fiber stimulation induces a Ca2+ rise in pre-myelinating OLs, which is primarily mediated by Ca2+-permeable AMPA receptors. During glutamate application, inward currents via AMPA receptors and elevated extracellular K+ caused by increased neuronal activity collectively lead to OL depolarization, triggering Ca2+ influx via P/Q- and L-type voltage-gated Ca2+ (Cav) channels. Thus, glutamate is a key signaling factor in dynamic communication between neurons and OLs that triggers Ca2+ transients via AMPARs and Cav channels in developing OLs. The results provide a mechanism for OL Ca2+ dynamics in response to neuronal input, which has implications for OL development and myelination.

Original languageEnglish (US)
Pages (from-to)1922-1932
Number of pages11
JournalGLIA
Volume67
Issue number10
DOIs
StatePublished - 2019

Keywords

  • AMPA receptor
  • Ca dynamics
  • neuron–glia interaction
  • oligodendrocytes
  • voltage-gated Ca channel

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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