Neuronal cells but not muscle cells are resistant to oxidative stress mediated protein misfolding and cell death: Role of molecular chaperones

Arunabh Bhattacharya, Rochelle Wei, Ryan T. Hamilton, Asish R. Chaudhuri

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Our recent study in a mouse model of familial-Amyotrophic Lateral Sclerosis (f-ALS) revealed that muscle proteins are equally sensitive to misfolding as spinal cord proteins despite the presence of low mutant CuZn-superoxide dismutase, which is considered to be the key toxic element for initiation and progression of f-ALS. More importantly, we observed differential level of heat shock proteins (Hsp's) between skeletal muscle and spinal cord tissues prior to the onset and during disease progression; spinal cord maintains significantly higher level of Hsp's compared to skeletal muscle. In this study, we report two important observations; (i) muscle cells (but not neuronal cells) are extremely vulnerable to protein misfolding and cell death during challenge with oxidative stress and (ii) muscle cells fail to mount Hsp's during challenge unlike neuronal cells these two findings can possibly explain why muscle atrophy precedes the death of motor neurons in f-ALS mice.

Original languageEnglish (US)
Pages (from-to)1250-1254
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume446
Issue number4
DOIs
StatePublished - Apr 18 2014

Keywords

  • Cell viability
  • Heat shock proteins
  • Neuron
  • Oxidative stress
  • Protein misfolding
  • Skeletal muscle

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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