Neuron-glial interactions in blood-brain barrier formation

Swati Banerjee, Manzoor Bhat

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

The blood brain barrier (BBB) evolved to preserve the microenvironment of the highly excitable neuronal cells to allow for action potential generation and propagation. Intricate molecular interactions between two main cell types, the neurons and the glial cells, form the underlying basis of the critical functioning of the nervous system across species. In invertebrates, interactions between neurons and glial cells are central in establishing a functional BBB. However, in vertebrates, the BBB formation and function is coordinated by interactions between neurons, glial cells, and endothelial cells. Here we review the neuron-glial interaction-based blood barriers in invertebrates and vertebrates and provide an evolutionary perspective as to how a glial-barrier system in invertebrates evolved into an endothelial barrier system. We also summarize the clinical relevance of the BBB as this protective barrier becomes disadvantageous in the pharmacological treatment of various neurological disorders.

Original languageEnglish (US)
Pages (from-to)235-258
Number of pages24
JournalAnnual Review of Neuroscience
Volume30
DOIs
StatePublished - 2007
Externally publishedYes

Fingerprint

Blood-Brain Barrier
Neuroglia
Neurons
Invertebrates
Vertebrates
Nervous System Diseases
Nervous System
Action Potentials
Endothelial Cells
Pharmacology

Keywords

  • Astrocytes
  • Drosophila
  • Endothelial cells
  • Neurovascular unit
  • Septate junctions
  • Tight junctions

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuron-glial interactions in blood-brain barrier formation. / Banerjee, Swati; Bhat, Manzoor.

In: Annual Review of Neuroscience, Vol. 30, 2007, p. 235-258.

Research output: Contribution to journalArticle

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