Neurological manifestations by sex and age group in COVID-19 inhospital patients

Daniella Nunes Pereira; Maria Aparecida Camargos Bicalho; Alzira de Oliveira Jorge; Angélica Gomides dos Reis Gomes; Alexandre Vargas Schwarzbold; Anna Luiza Homan Araújo; Christiane Corrêa Rodrigues Cimini; Daniela Ponce; Danyelle Romana Alves Rios; Genna Maira Santos Grizende; Euler Roberto Fernandes Manenti; Fernando Anschau; Fernando Graça Aranha; Frederico Bartolazzi; Joanna d.Arc Lyra Batista; Julia Teixeira Tupinambás; Karen Brasil Ruschel; Maria Angélica Pires Ferreira; Pedro Gibson Paraíso; Silvia Ferreira Araújo; Antonio Lucio Teixeira; Milena Soriano Marcolino

doi:10.1016/j.ensci.2022.100419

Neurological manifestations by sex and age group in COVID-19 inhospital patients

Daniella Nunes Pereira, Maria Aparecida Camargos Bicalho, Alzira de Oliveira Jorge, Angélica Gomides dos Reis Gomes, Alexandre Vargas Schwarzbold, Anna Luiza Homan Araújo, Christiane Corrêa Rodrigues Cimini, Daniela Ponce, Danyelle Romana Alves Rios, Genna Maira Santos Grizende, Euler Roberto Fernandes Manenti, Fernando Anschau, Fernando Graça Aranha, Frederico Bartolazzi, Joanna d.Arc Lyra Batista, Julia Teixeira Tupinambás, Karen Brasil Ruschel, Maria Angélica Pires Ferreira, Pedro Gibson Paraíso, Silvia Ferreira AraújoAntonio Lucio Teixeira, Milena Soriano Marcolino

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Introduction: Neurological manifestations have been associated with a poorer prognosis in COVID-19. However, data regarding their incidence according to sex and age groups is still lacking. Methods: This retrospective multicentric cohort collected data from 39 Brazilian hospitals from 17 cities, from adult COVID-19 admitted from March 2020 to January 2022. Neurological manifestations presented at hospital admission were assessed according to incidence by sex and age group. Results: From 13,603 COVID-19 patients, median age was 60 years old and 53.0% were men. Women were more likely to present with headaches (22.4% vs. 17.7%, p < 0.001; OR 1.36, 95% confidence interval [CI] 1.22–1.52) than men and also presented a lower risk of having seizures (OR 0.43, 95% CI 0.20–0.94). Although delirium was more frequent in women (6.6% vs. 5.7%, p = 0.020), sex was not associated with delirium in the multivariable logistc regresssion analysis. Delirium, syncope and coma increased with age (1.5% [18–39 years] vs. 22.4% [80 years or over], p < 0.001, OR 1.07, 95% CI 1.06–1.07; 0.7% vs. 1.7%, p = 0.002, OR 1.01, 95% CI 1.00–1.02; 0.2% vs. 1.3% p < 0.001, OR 1.04, 95% CI 1.02–1.06), while, headache (26.5% vs. 7.1%, OR 0.98, 95% CI 0.98–0.99), anosmia (11.4% vs. 3.3%, OR 0.99, 95% CI] 0.98–0.99 and ageusia (13.1% vs. 3.5%, OR 0.99, CI 0.98–0.99) decreased (p < 0.001 for all). Conclusion: Older COVID-19 patients were more likely to present delirium, syncope and coma, while the incidence of anosmia, ageusia and headaches decreased with age. Women were more likely to present headache, and less likely to present seizures.

Original language	English (US)
Article number	100419
Journal	eNeurologicalSci
Volume	28
DOIs	https://doi.org/10.1016/j.ensci.2022.100419
State	Published - Sep 2022
Externally published	Yes

Keywords

Age
COVID-19
Delirium
Neurological manifestations
Sex

ASJC Scopus subject areas

Neurology

Access to Document

10.1016/j.ensci.2022.100419

Cite this

Pereira, D. N., Bicalho, M. A. C., Jorge, A. D. O., Gomes, A. G. D. R., Schwarzbold, A. V., Araújo, A. L. H., Cimini, C. C. R., Ponce, D., Rios, D. R. A., Grizende, G. M. S., Manenti, E. R. F., Anschau, F., Aranha, F. G., Bartolazzi, F., Batista, J. D. A. L., Tupinambás, J. T., Ruschel, K. B., Ferreira, M. A. P., Paraíso, P. G., ... Marcolino, M. S. (2022). Neurological manifestations by sex and age group in COVID-19 inhospital patients. eNeurologicalSci, 28, Article 100419. https://doi.org/10.1016/j.ensci.2022.100419

Pereira, DN, Bicalho, MAC, Jorge, ADO, Gomes, AGDR, Schwarzbold, AV, Araújo, ALH, Cimini, CCR, Ponce, D, Rios, DRA, Grizende, GMS, Manenti, ERF, Anschau, F, Aranha, FG, Bartolazzi, F, Batista, JDAL, Tupinambás, JT, Ruschel, KB, Ferreira, MAP, Paraíso, PG, Araújo, SF, Teixeira, AL & Marcolino, MS 2022, 'Neurological manifestations by sex and age group in COVID-19 inhospital patients', eNeurologicalSci, vol. 28, 100419. https://doi.org/10.1016/j.ensci.2022.100419

@article{0736dead97674490af90ca09eac2856a,

title = "Neurological manifestations by sex and age group in COVID-19 inhospital patients",

abstract = "Introduction: Neurological manifestations have been associated with a poorer prognosis in COVID-19. However, data regarding their incidence according to sex and age groups is still lacking. Methods: This retrospective multicentric cohort collected data from 39 Brazilian hospitals from 17 cities, from adult COVID-19 admitted from March 2020 to January 2022. Neurological manifestations presented at hospital admission were assessed according to incidence by sex and age group. Results: From 13,603 COVID-19 patients, median age was 60 years old and 53.0% were men. Women were more likely to present with headaches (22.4% vs. 17.7%, p < 0.001; OR 1.36, 95% confidence interval [CI] 1.22–1.52) than men and also presented a lower risk of having seizures (OR 0.43, 95% CI 0.20–0.94). Although delirium was more frequent in women (6.6% vs. 5.7%, p = 0.020), sex was not associated with delirium in the multivariable logistc regresssion analysis. Delirium, syncope and coma increased with age (1.5% [18–39 years] vs. 22.4% [80 years or over], p < 0.001, OR 1.07, 95% CI 1.06–1.07; 0.7% vs. 1.7%, p = 0.002, OR 1.01, 95% CI 1.00–1.02; 0.2% vs. 1.3% p < 0.001, OR 1.04, 95% CI 1.02–1.06), while, headache (26.5% vs. 7.1%, OR 0.98, 95% CI 0.98–0.99), anosmia (11.4% vs. 3.3%, OR 0.99, 95% CI] 0.98–0.99 and ageusia (13.1% vs. 3.5%, OR 0.99, CI 0.98–0.99) decreased (p < 0.001 for all). Conclusion: Older COVID-19 patients were more likely to present delirium, syncope and coma, while the incidence of anosmia, ageusia and headaches decreased with age. Women were more likely to present headache, and less likely to present seizures.",

keywords = "Age, COVID-19, Delirium, Neurological manifestations, Sex",

author = "Pereira, {Daniella Nunes} and Bicalho, {Maria Aparecida Camargos} and Jorge, {Alzira de Oliveira} and Gomes, {Ang{\'e}lica Gomides dos Reis} and Schwarzbold, {Alexandre Vargas} and Ara{\'u}jo, {Anna Luiza Homan} and Cimini, {Christiane Corr{\^e}a Rodrigues} and Daniela Ponce and Rios, {Danyelle Romana Alves} and Grizende, {Genna Maira Santos} and Manenti, {Euler Roberto Fernandes} and Fernando Anschau and Aranha, {Fernando Gra{\c c}a} and Frederico Bartolazzi and Batista, {Joanna d.Arc Lyra} and Tupinamb{\'a}s, {Julia Teixeira} and Ruschel, {Karen Brasil} and Ferreira, {Maria Ang{\'e}lica Pires} and Para{\'i}so, {Pedro Gibson} and Ara{\'u}jo, {Silvia Ferreira} and Teixeira, {Antonio Lucio} and Marcolino, {Milena Soriano}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = sep,

doi = "10.1016/j.ensci.2022.100419",

language = "English (US)",

volume = "28",

journal = "eNeurologicalSci",

issn = "2405-6502",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Neurological manifestations by sex and age group in COVID-19 inhospital patients

AU - Pereira, Daniella Nunes

AU - Bicalho, Maria Aparecida Camargos

AU - Jorge, Alzira de Oliveira

AU - Gomes, Angélica Gomides dos Reis

AU - Schwarzbold, Alexandre Vargas

AU - Araújo, Anna Luiza Homan

AU - Cimini, Christiane Corrêa Rodrigues

AU - Ponce, Daniela

AU - Rios, Danyelle Romana Alves

AU - Grizende, Genna Maira Santos

AU - Manenti, Euler Roberto Fernandes

AU - Anschau, Fernando

AU - Aranha, Fernando Graça

AU - Bartolazzi, Frederico

AU - Batista, Joanna d.Arc Lyra

AU - Tupinambás, Julia Teixeira

AU - Ruschel, Karen Brasil

AU - Ferreira, Maria Angélica Pires

AU - Paraíso, Pedro Gibson

AU - Araújo, Silvia Ferreira

AU - Teixeira, Antonio Lucio

AU - Marcolino, Milena Soriano

PY - 2022/9

Y1 - 2022/9

N2 - Introduction: Neurological manifestations have been associated with a poorer prognosis in COVID-19. However, data regarding their incidence according to sex and age groups is still lacking. Methods: This retrospective multicentric cohort collected data from 39 Brazilian hospitals from 17 cities, from adult COVID-19 admitted from March 2020 to January 2022. Neurological manifestations presented at hospital admission were assessed according to incidence by sex and age group. Results: From 13,603 COVID-19 patients, median age was 60 years old and 53.0% were men. Women were more likely to present with headaches (22.4% vs. 17.7%, p < 0.001; OR 1.36, 95% confidence interval [CI] 1.22–1.52) than men and also presented a lower risk of having seizures (OR 0.43, 95% CI 0.20–0.94). Although delirium was more frequent in women (6.6% vs. 5.7%, p = 0.020), sex was not associated with delirium in the multivariable logistc regresssion analysis. Delirium, syncope and coma increased with age (1.5% [18–39 years] vs. 22.4% [80 years or over], p < 0.001, OR 1.07, 95% CI 1.06–1.07; 0.7% vs. 1.7%, p = 0.002, OR 1.01, 95% CI 1.00–1.02; 0.2% vs. 1.3% p < 0.001, OR 1.04, 95% CI 1.02–1.06), while, headache (26.5% vs. 7.1%, OR 0.98, 95% CI 0.98–0.99), anosmia (11.4% vs. 3.3%, OR 0.99, 95% CI] 0.98–0.99 and ageusia (13.1% vs. 3.5%, OR 0.99, CI 0.98–0.99) decreased (p < 0.001 for all). Conclusion: Older COVID-19 patients were more likely to present delirium, syncope and coma, while the incidence of anosmia, ageusia and headaches decreased with age. Women were more likely to present headache, and less likely to present seizures.

AB - Introduction: Neurological manifestations have been associated with a poorer prognosis in COVID-19. However, data regarding their incidence according to sex and age groups is still lacking. Methods: This retrospective multicentric cohort collected data from 39 Brazilian hospitals from 17 cities, from adult COVID-19 admitted from March 2020 to January 2022. Neurological manifestations presented at hospital admission were assessed according to incidence by sex and age group. Results: From 13,603 COVID-19 patients, median age was 60 years old and 53.0% were men. Women were more likely to present with headaches (22.4% vs. 17.7%, p < 0.001; OR 1.36, 95% confidence interval [CI] 1.22–1.52) than men and also presented a lower risk of having seizures (OR 0.43, 95% CI 0.20–0.94). Although delirium was more frequent in women (6.6% vs. 5.7%, p = 0.020), sex was not associated with delirium in the multivariable logistc regresssion analysis. Delirium, syncope and coma increased with age (1.5% [18–39 years] vs. 22.4% [80 years or over], p < 0.001, OR 1.07, 95% CI 1.06–1.07; 0.7% vs. 1.7%, p = 0.002, OR 1.01, 95% CI 1.00–1.02; 0.2% vs. 1.3% p < 0.001, OR 1.04, 95% CI 1.02–1.06), while, headache (26.5% vs. 7.1%, OR 0.98, 95% CI 0.98–0.99), anosmia (11.4% vs. 3.3%, OR 0.99, 95% CI] 0.98–0.99 and ageusia (13.1% vs. 3.5%, OR 0.99, CI 0.98–0.99) decreased (p < 0.001 for all). Conclusion: Older COVID-19 patients were more likely to present delirium, syncope and coma, while the incidence of anosmia, ageusia and headaches decreased with age. Women were more likely to present headache, and less likely to present seizures.

KW - Age

KW - COVID-19

KW - Delirium

KW - Neurological manifestations

KW - Sex

UR - http://www.scopus.com/inward/record.url?scp=85136248005&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85136248005&partnerID=8YFLogxK

U2 - 10.1016/j.ensci.2022.100419

DO - 10.1016/j.ensci.2022.100419

M3 - Article

AN - SCOPUS:85136248005

SN - 2405-6502

VL - 28

JO - eNeurologicalSci

JF - eNeurologicalSci

M1 - 100419

ER -

Neurological manifestations by sex and age group in COVID-19 inhospital patients

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this