Neurological aspects of antiphospholipid antibody syndrome

S. R. Levine, R. L. Brey

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

Antiphospholipid antibodies (aPL) have been associated with a variety of neurological disorders, mostly linked to focal neuroparenchymal ischemia or infarction. Cerebral ischemia associated with the antiphospholipid syndrome (APS) occurs at a younger age than typical atherothrombotic cerebrovascular disease, is often recurrent, and high positive GPL values are usually linked to the presence of a lupus anticoagulant. When other features of the syndrome are not present and cerebral ischemia occurs only associated with anticardiolipin immunoreactivity, there appears to be no discerning features of these patients unless GPL > 40 for which recurrent thrombo-occlusive events appear to occur more frequently. Other neurological manifestations associated with aPL include cerebral venous sinus thrombosis, ocular ischemia, dementia, including ischemic encephalopathy, and chorea. The role of aPL in migrainous events is controversial and may not play a role in recent, large case-controlled studies. Most seizures in patients harboring aPL are associated with focal brain infarction.

Original languageEnglish (US)
Pages (from-to)347-353
Number of pages7
JournalLupus
Volume5
Issue number5
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

Keywords

  • Anticardiolipin antibody
  • Antiphospholipid syndrome
  • Chorea
  • Lupus anticoagulant
  • Migraine
  • Seizures
  • Stroke
  • Thrombosis
  • Transverse myelitis

ASJC Scopus subject areas

  • Rheumatology

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