Neurological and Psychiatric Disorders in Patients with Rheumatic Heart Disease: Unveiling what is Beyond Cardiac Manifestations

Luiz Paulo Bastos Vasconcelos, Marcelle Cristina da Silva Bastos Vasconcelos, Francisco Biagio Murta E. Di Flora, Flávio Augusto Paes de Oliveira, Pedro Drummond Lima, Lucas Campos Barbosa E. Silva, Breno Camargos Mucelli Spolaor, José Luiz Padilha da Silva, William Antônio de Magalhães Esteves, Maria Carmo P. Nunes, Antônio Lúcio Teixeira

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Rheumatic heart disease (RHD) is the most serious manifestation of rheumatic fever, which may also affect the brain. The current study assessed the prevalence of neuropsychiatric manifestations in patients with RHD, including clinical features associated with basal ganglia motor dysfunction (BGMD). Methods: We conducted neurologic and psychiatric assessments in consecutive patients with RHD referred to a tertiary center for heart valve diseases. Echocardiography was performed to assess the pattern of valvular involvement and RHD severity. Validated questionnaires for the evaluation of cognition, depression, anxiety, and obsessive-compulsive symptoms (OCS) were applied. BGMD was clinically defined by the presence of hyperkinetic movement disorders. Results: Fifty patients with age of 43.2 ± 10.8 years, 84% female, were included. Mitral valve was affected in 47 patients (94%), and 21 of them (42%) also had aortic valve involvement. Chorea (22%), chronic tics (18%), OCS (48%), major depression (34%), generalized anxiety disorder (54%), cognitive complaints (66%), migraine (52%) and seizures (18%) were frequently reported. The factors associated with BGMD were age (p = 0.018), major depression (p = 0.013), and Yale-Brown Obsessive Compulsive (Y-BOCS) score (p = 0.011). The severity of heart disease was not associated with BGMD. Conclusions: Neuropsychiatric manifestations are frequent in RHD patients, which may persist up to three decades after acute rheumatic fever. Age, major depression and severity of OCS were independently associated with BGMD. These manifestations deserve a close attention of clinicians and researchers dealing with adult patients with RHD.

Original languageEnglish (US)
Article number62
JournalGlobal Heart
Volume17
Issue number1
DOIs
StatePublished - 2022
Externally publishedYes

Keywords

  • basal ganglia motor dysfunction
  • migraine
  • mood disorders
  • obsessive-compulsive symptoms
  • Rheumatic heart disease

ASJC Scopus subject areas

  • Epidemiology
  • Community and Home Care
  • Cardiology and Cardiovascular Medicine

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