Abstract
Antiphopholipid antibodies are highly associated with venous and arterial thrombotic episodes, which are often recurrent. Although cerebral and ocular ischemia are the most common neurologic complications of antiphospholipid antibodies, a variety of neurologic syndromes has been associated with them. Recent reports using in vitro systems and animal models strongly suggest that these antibodies may be directly implicated in the pathogenesis of thrombosis rather than simply being markers of a procoagulable state. This article discusses the laboratory diagnosis, clinical features, and treatment of neurologic disease associated with antiphospholipid antibodies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 833-850 |
| Number of pages | 18 |
| Journal | Rheumatic Disease Clinics of North America |
| Volume | 19 |
| Issue number | 4 |
| State | Published - 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Rheumatology
Cite this
Neurologic complications of antiphospholipid antibodies. / Brey, Robin L; Gharavi, A. E.; Lockshin, M. D.
In: Rheumatic Disease Clinics of North America, Vol. 19, No. 4, 1993, p. 833-850.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurologic complications of antiphospholipid antibodies
AU - Brey, Robin L
AU - Gharavi, A. E.
AU - Lockshin, M. D.
PY - 1993
Y1 - 1993
N2 - Antiphopholipid antibodies are highly associated with venous and arterial thrombotic episodes, which are often recurrent. Although cerebral and ocular ischemia are the most common neurologic complications of antiphospholipid antibodies, a variety of neurologic syndromes has been associated with them. Recent reports using in vitro systems and animal models strongly suggest that these antibodies may be directly implicated in the pathogenesis of thrombosis rather than simply being markers of a procoagulable state. This article discusses the laboratory diagnosis, clinical features, and treatment of neurologic disease associated with antiphospholipid antibodies.
AB - Antiphopholipid antibodies are highly associated with venous and arterial thrombotic episodes, which are often recurrent. Although cerebral and ocular ischemia are the most common neurologic complications of antiphospholipid antibodies, a variety of neurologic syndromes has been associated with them. Recent reports using in vitro systems and animal models strongly suggest that these antibodies may be directly implicated in the pathogenesis of thrombosis rather than simply being markers of a procoagulable state. This article discusses the laboratory diagnosis, clinical features, and treatment of neurologic disease associated with antiphospholipid antibodies.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027430207&partnerID=8YFLogxK
M3 - Article
C2 - 8265825
AN - SCOPUS:0027430207
VL - 19
SP - 833
EP - 850
JO - Rheumatic Disease Clinics of North America
JF - Rheumatic Disease Clinics of North America
SN - 0889-857X
IS - 4
ER -