Neurologic complications of antiphospholipid antibodies

R. L. Brey, A. E. Gharavi, M. D. Lockshin

Research output: Contribution to journalReview articlepeer-review

82 Scopus citations


Antiphopholipid antibodies are highly associated with venous and arterial thrombotic episodes, which are often recurrent. Although cerebral and ocular ischemia are the most common neurologic complications of antiphospholipid antibodies, a variety of neurologic syndromes has been associated with them. Recent reports using in vitro systems and animal models strongly suggest that these antibodies may be directly implicated in the pathogenesis of thrombosis rather than simply being markers of a procoagulable state. This article discusses the laboratory diagnosis, clinical features, and treatment of neurologic disease associated with antiphospholipid antibodies.

Original languageEnglish (US)
Pages (from-to)833-850
Number of pages18
JournalRheumatic Disease Clinics of North America
Issue number4
StatePublished - Jan 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • Rheumatology


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