Neuroleptic addition in fluvoxamine-refractory obsessive-compulsive disorder

Christopher J. McDougle; Wayne K. Goodman; Lawrence H. Price; Pedro L. Delgado; John H. Krystal; Dennis S. Charney; George R. Heninger

doi:10.1176/ajp.147.5.652

Neuroleptic addition in fluvoxamine-refractory obsessive-compulsive disorder

Christopher J. McDougle, Wayne K. Goodman, Lawrence H. Price, Pedro L. Delgado, John H. Krystal, Dennis S. Charney, George R. Heninger

Joe R & Teresa Lozano Long School of Medicine

Research output: Contribution to journal › Article › peer-review

109 Scopus citations

Abstract

Nine of 17 patients with obsessive-compulsive disorder responded when neuroleptic was added to fluvoxamine with or without lithium. Comorbid occurrence of tic spectrum disorders or of schizotypal personality disorder was associated with response. Abnormalities in brain dopamine and serotonin may be implicated in such Patients.

Original language	English (US)
Pages (from-to)	652-654
Number of pages	3
Journal	American Journal of Psychiatry
Volume	147
Issue number	5
DOIs	https://doi.org/10.1176/ajp.147.5.652
State	Published - 1990

ASJC Scopus subject areas

Psychiatry and Mental health

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10.1176/ajp.147.5.652

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title = "Neuroleptic addition in fluvoxamine-refractory obsessive-compulsive disorder",

abstract = "Nine of 17 patients with obsessive-compulsive disorder responded when neuroleptic was added to fluvoxamine with or without lithium. Comorbid occurrence of tic spectrum disorders or of schizotypal personality disorder was associated with response. Abnormalities in brain dopamine and serotonin may be implicated in such Patients.",

author = "McDougle, {Christopher J.} and Goodman, {Wayne K.} and Price, {Lawrence H.} and Delgado, {Pedro L.} and Krystal, {John H.} and Charney, {Dennis S.} and Heninger, {George R.}",

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AU - McDougle, Christopher J.

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AU - Delgado, Pedro L.

AU - Krystal, John H.

AU - Charney, Dennis S.

AU - Heninger, George R.

PY - 1990

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N2 - Nine of 17 patients with obsessive-compulsive disorder responded when neuroleptic was added to fluvoxamine with or without lithium. Comorbid occurrence of tic spectrum disorders or of schizotypal personality disorder was associated with response. Abnormalities in brain dopamine and serotonin may be implicated in such Patients.

AB - Nine of 17 patients with obsessive-compulsive disorder responded when neuroleptic was added to fluvoxamine with or without lithium. Comorbid occurrence of tic spectrum disorders or of schizotypal personality disorder was associated with response. Abnormalities in brain dopamine and serotonin may be implicated in such Patients.

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Neuroleptic addition in fluvoxamine-refractory obsessive-compulsive disorder

Abstract

ASJC Scopus subject areas

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