Neuroleptic addition in fluvoxamine-refractory obsessive-compulsive disorder

Christopher J. McDougle, Wayne K. Goodman, Lawrence H. Price, Pedro L. Delgado, John H. Krystal, Dennis S. Charney, George R. Heninger

Research output: Contribution to journalArticle

238 Scopus citations


Nine of 17 patients with obsessive-compulsive disorder responded when neuroleptic was added to fluvoxamine with or without lithium. Comorbid occurrence of tic spectrum disorders or of schizotypal personality disorder was associated with response. Abnormalities in brain dopamine and serotonin may be implicated in such Patients.

Original languageEnglish (US)
Pages (from-to)652-654
Number of pages3
JournalAmerican Journal of Psychiatry
Issue number5
StatePublished - 1990

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    McDougle, C. J., Goodman, W. K., Price, L. H., Delgado, P. L., Krystal, J. H., Charney, D. S., & Heninger, G. R. (1990). Neuroleptic addition in fluvoxamine-refractory obsessive-compulsive disorder. American Journal of Psychiatry, 147(5), 652-654.