Abstract
The classical description of the nervous, the immune, and the endocrine systems as independent components has been challenged by studies investigating the relationship among them. A growing body of evidence points to the bidirectional communication between neuroendocrine and immune systems through different routes. In this regard, not only central nervous system (CNS) conditions (e.g., stress) can influence the immune system through endocrine communication, but also immune changes (e.g., due to infection) might affect CNS functions, resulting, for instance, in depressive-like behaviors. In this chapter, we present basic and clinical evidence of the crosstalk between immune, endocrine, and nervous systems.
Original language | English (US) |
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Title of host publication | Nijkamp and Parnham’s Principles of Immunopharmacology |
Subtitle of host publication | Fourth revised and extended edition |
Publisher | Springer International Publishing |
Pages | 209-230 |
Number of pages | 22 |
ISBN (Electronic) | 9783030108113 |
ISBN (Print) | 9783030108090 |
DOIs | |
State | Published - Jan 1 2019 |
Externally published | Yes |
Keywords
- Cytokines
- Depression
- Hormones
- Hypothalamic-pituitary-adrenal axis
- Immunopsychiatry
- Leukocytes
- Neuroimmunoendocrinology
- Sickness behavior
- Stress
ASJC Scopus subject areas
- General Medicine
- General Immunology and Microbiology
- General Pharmacology, Toxicology and Pharmaceutics
- General Biochemistry, Genetics and Molecular Biology