Neuroimmunoendocrinology

Natalia P. Rocha, Moises E. Bauer, Antonio L. Teixeira

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The classical description of the nervous, the immune, and the endocrine systems as independent components has been challenged by studies investigating the relationship among them. A growing body of evidence points to the bidirectional communication between neuroendocrine and immune systems through different routes. In this regard, not only central nervous system (CNS) conditions (e.g., stress) can influence the immune system through endocrine communication, but also immune changes (e.g., due to infection) might affect CNS functions, resulting, for instance, in depressive-like behaviors. In this chapter, we present basic and clinical evidence of the crosstalk between immune, endocrine, and nervous systems.

Original languageEnglish (US)
Title of host publicationNijkamp and Parnham’s Principles of Immunopharmacology
Subtitle of host publicationFourth revised and extended edition
PublisherSpringer International Publishing
Pages209-230
Number of pages22
ISBN (Electronic)9783030108113
ISBN (Print)9783030108090
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Keywords

  • Cytokines
  • Depression
  • Hormones
  • Hypothalamic-pituitary-adrenal axis
  • Immunopsychiatry
  • Leukocytes
  • Neuroimmunoendocrinology
  • Sickness behavior
  • Stress

ASJC Scopus subject areas

  • General Medicine
  • General Immunology and Microbiology
  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology

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