Neurohormonal Activation in Populations Susceptible to Heart Failure

Johan Ärnlöv, Ramachandran S. Vasan

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


This article discusses the adverse effects of neurohormonal activation in populations susceptible to chronic heart failure (CHF). The authors define neurohormonal activation, trace the contributions of relevant pathways to the development of subclinical left ventricular dysfunction and CHF, and summarize data on the evolution of neurohormonal antagonism as a therapeutic tool to prevent CHF, focusing on clinical studies that have evaluated circulating levels of neurohormones. The roles of the RAAS, catecholamines, endothelins, and the natriuretic peptides are described.

Original languageEnglish (US)
Pages (from-to)11-23
Number of pages13
JournalHeart Failure Clinics
Issue number1
StatePublished - Apr 2005
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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