TY - JOUR
T1 - Neurohormonal Activation in Populations Susceptible to Heart Failure
AU - Ärnlöv, Johan
AU - Vasan, Ramachandran S.
PY - 2005/4
Y1 - 2005/4
N2 - This article discusses the adverse effects of neurohormonal activation in populations susceptible to chronic heart failure (CHF). The authors define neurohormonal activation, trace the contributions of relevant pathways to the development of subclinical left ventricular dysfunction and CHF, and summarize data on the evolution of neurohormonal antagonism as a therapeutic tool to prevent CHF, focusing on clinical studies that have evaluated circulating levels of neurohormones. The roles of the RAAS, catecholamines, endothelins, and the natriuretic peptides are described.
AB - This article discusses the adverse effects of neurohormonal activation in populations susceptible to chronic heart failure (CHF). The authors define neurohormonal activation, trace the contributions of relevant pathways to the development of subclinical left ventricular dysfunction and CHF, and summarize data on the evolution of neurohormonal antagonism as a therapeutic tool to prevent CHF, focusing on clinical studies that have evaluated circulating levels of neurohormones. The roles of the RAAS, catecholamines, endothelins, and the natriuretic peptides are described.
UR - http://www.scopus.com/inward/record.url?scp=33646185897&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646185897&partnerID=8YFLogxK
U2 - 10.1016/j.hfc.2004.11.003
DO - 10.1016/j.hfc.2004.11.003
M3 - Review article
C2 - 17386830
AN - SCOPUS:33646185897
SN - 1551-7136
VL - 1
SP - 11
EP - 23
JO - Heart Failure Clinics
JF - Heart Failure Clinics
IS - 1
ER -