Neuroglian is expressed on cells destined to form the prothoracic glands of Manduca embryos as they segregate from surrounding cells and rearrange during morphogenesis

Chun-liang Chen, David J. Lampe, Hugh M. Robertson, James B. Nardi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A cell surface protein (3B11) is differentially expressed in the embryonic labial segment of Manduca as two circular monolayers of epithelial cells invaginate and segregate from surrounding epithelial cells. The cells that invaginate and preferentially express 3B11 represent the presumptive prothoracic glands. These cells continue to express protein 3B11 as they rearrange to form first a three-dimensional aggregate and later anastomosing filaments of cells. In the differentiated prothoracic gland, expression of 3B11 is restricted to sites of cell-cell contact. Cloning and sequencing of the cDNA for protein 3B11 revealed that this protein is the Manduca counterpart of Drosophila neuroglian and mouse L1. These surface proteins are known to function as adhesion/recognition molecules during development. Manduca neuroglian shares 58 and 31% identity respectively with the Drosophila and mouse proteins and has a cytoplasmic domain of over 100 amino acids.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalDevelopmental Biology
Volume181
Issue number1
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

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Manduca
Morphogenesis
Embryonic Structures
Membrane Proteins
Epithelial Cells
Lip
Drosophila
Organism Cloning
Complementary DNA
Amino Acids
protein 3B11
Proteins

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Neuroglian is expressed on cells destined to form the prothoracic glands of Manduca embryos as they segregate from surrounding cells and rearrange during morphogenesis. / Chen, Chun-liang; Lampe, David J.; Robertson, Hugh M.; Nardi, James B.

In: Developmental Biology, Vol. 181, No. 1, 01.01.1997, p. 1-13.

Research output: Contribution to journalArticle

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